HEALTH
EFFECTS: Variable Length of Exposure Producing Fluorosis
DIRECTORY: FAN
> Health >
Bone >
Fluorosis
> Variability
> Duration of Exposure
Varying Individual Sensitivites
to Fluoride - Variable
Length of Exposure Producing Fluorosis Among Workers in Same Workplace
"Individual differences in sensitivity
to noxious fluoride seems to be important... [I]t
is quite possible to be an aluminum smelter worker for 30 years
or longer without showing fluoride-caused bone changes, whereas
others develop symptoms of fluorosis after only 10 years;
the varying effect of fluoride has been demonstrated
by therapy tests for osteoporosis."
SOURCE: Runge H, Franke J. (1989). Radiological modifications
of the skeletal system among aluminum smelter workers: A 15 year
retrospective study. Fluoride 22: 157-164.
"Cases of the 1st phase were observed
after 2 5/12 years work, of the 2nd phase after 4 10/12 years,
of the 3rd phase after 11 2/12 years. On the other hand the changes
were slight in a certain number of the workers, even after long
employment...One female worker had no bone changes, though
she had been employed for 24 years with one interruption."
SOURCE: Roholm K. (1937). Fluoride intoxication: a clinical-hygienic
study with a review of the literature and some experimental investigations.
London: H.K. Lewis Ltd.
"As regards the bone changes... they were
pronounced in one male worker who had only been in the factory
5 years, and rather severe also in two female workers who had
only been there 6 years."
SOURCE: Moller P, Gudjonsson SV. (1932). Massive fluorosis of
bones and ligaments. Acta Radiologica 12: 269-294
| Variations
in Individual Susceptibility to Fluoride:
Duration of Exposure Producing
Fluorosis |
Study |
Phase of
Skeletal Fluorosis |
Average
Exposure
(years) |
Shortest
Exposure
(years) |
Longest
Exposure
(years) |
Roholm 1937 |
No Changes |
8 |
2.8 |
24 |
Roholm 1937 |
Clinical Phase 1 |
9.3 |
2.4 |
33.8 |
Roholm 1937 |
Clinical Phase 2 |
9.7 |
4.8 |
28.9 |
Roholm 1937 |
Clinical Phase 3 |
21.1 |
11.2 |
31.2 |
|
|
|
|
|
Franke 1975 |
Vague Symptoms |
10.71 |
2 |
25 |
Franke 1975 |
Stage O-I |
12.15 |
5 |
33 |
Franke 1975 |
Clinical Phase 1 |
15.7 |
8 |
38 |
Franke 1975 |
Clinical Phase 2 |
17.6 |
11 |
21 |
Franke 1975 |
Clinical Phase 3 |
19.5 |
19 |
20 |
|
|
|
|
|
Runge 1989 |
No Changes |
19.9 |
5 |
35 |
Runge 1989 |
Vague Symptoms |
19.2 |
10 |
37 |
Runge 1989 |
Stage O-I |
22.6 |
10 |
30 |
Runge 1989 |
Clinical Phase 1 |
21.1 |
10 |
43 |
Runge 1989 |
Clinical Phase 1-2 |
21.1 |
10 |
33 |
Runge 1989 |
Clinical Phase 2 |
17.5 |
16 |
19 |
Runge 1989 |
Clinical Phase 2-3 |
21.3 |
15 |
26 |
| |
|
|
|
|
| SOURCE of DATA:
Roholm K. (1937). Fluoride intoxication: a
clinical-hygienic study with a review of the literature
and some experimental investigations. London: H.K. Lewis
Ltd.
Franke J, et al. (1975). Industrial fluorosis.
Fluoride 8: 61-83.
Runge H, Franke J. (1989). Radiological modifications
of the skeletal system among aluminum smelter workers: A
15 year retrospective study. Fluoride 22: 157-164.
|
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