latest news: Chemical Weapons
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Repeated low-dose exposures to sarin disrupted the homeostasis of phospholipid and sphingolipid metabolism in guinea pig hippocampus.
Note from FAN: The molecular structure of Sarin: Highlights Repeated low-dose sarin disturbed the cognitive ability in guinea pigs. Sarin disturbed phospholipid and sphingolipid metabolism in hippocampus. Neuropathy target esterase plays an important role on phospholipid metabolism. Biological function of identified metabolites that against sarin lesions need to be studied. Abstract Repeated low-level exposure to […]International Chemical Weapons
No promising antidote 25 years after the Tokyo subway sarin attack: A review.
Note from FAN: The molecular structure of Sarin: Highlights This year marks 25 years since the Tokyo subway sarin attack. 2-PAM is the most widely used antidote in hospitals despite poor BBB permeability. We are trying to develop a reactivator that can easily cross the BBB. There are still no promising oximes that are safe, […]International Chemical Weapons
A Fluorogenic and Chromogenic Probe Distinguishes Fluoride Anions and Thiols: Implications for Discrimination of Fluoride-Containing G Series and Sulfur-Containing V Series Nerve Agents.
Abstract A coumarin-based probe, FP2, was designed for the differential detection of fluoride anions and thiols, i.e., the corresponding nucleophilic substitution products from fluorine-containing G agents and sulfur-containing V agents, thus having the potential to discriminate between these two nerve agents. FP2 with two functional reaction groups, a, B-unsaturated ketone and silyl groups, can react […]China Chemical Weapons
Rapid destruction of sarin surrogates by gas phase reactions with focus on diisopropyl methylphosphonate (DIMP).
Note from FAN: The molecular structure of Sarin: Abstract Rapid destruction of stockpiles of sarin and other chemical weapon agents (CWA) requires understanding and quantitative description of the relevant chemical reactions. Rapid reactions at elevated temperatures are of particular interest for prompt agent defeat scenarios. Diisopropyl methylphosphonate (DIMP) is a sarin surrogate particularly well suited […]International Chemical Weapons
Fluoride reactivation-enabled sensitive quantification of tabun adducts on human serum albumin by GC-MS/MS via isotope dilution.
Organophosphorus nerve agents inhibit the cholinesterase activity by phosphylation of the active site serine. The resulting phosphylated cholinesterase and adducts on human serum albumin (HSA) are appropriate biomarkers for nerve agents exposure. Several methods have been developed for the detection of nerve agents, including fluoride reactivation or alkaline cleavage. It was previously thought that some […]International Chemical Weapons
Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action.
Abstract The ability of mono N-methyl-1,4-diazabicyclo[2.2.2]octane fluoride (Me-DABCOF, 1) to act as a bifunctional reagent that effectively and universally neutralizes both the persistent and extremely toxic blister agent HD and the nerve agent VX in nearly neutral aqueous solution, alumina powder or a hydrogel formulation, is described. *Original abstract online at https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC07011G#!divAbstract Print PDFInternational Chemical Weapons
Japan made over 30 illegal shipments to North Korea: lawmaker
Kicker: Japanese media outlet’s report accusing South Korea of unlawful exports to the North took information out of context Lawmaker Ha Tae-keung of the minor opposition Bareunmirae Party on Thursday alleged that Japan smuggled hydrogen fluoride and materials used to develop biochemical weapons to North Korea. According to Ha, Japan made over 30 shipments of […]Japan Chemical Weapons
Oberon remembers Chris Freeman
OBERON was saddened to hear of the sudden passing of well-known and respected citizen Chris Whitmee, also known as Chris Freeman. Mr Freeman, 49, died of natural causes while visiting his family in Brisbane. Well-known for his involvement in the Say No To Fluoride campaign, he was also involved in a rally at the Oberon […]Australia Chemical Weapons
Systematic Review of Long-Term Neurological Effects following Acute Exposure to the Organophosphorus Nerve Agent Sarin
Structural formula for Sarin Abstract: Background Sarin (CASRN: 107-44-8) is a highly toxic organophosphorus nerve agent that was developed for chemical warfare during World War II and continues to be used in conflicts. Immediate effects of sarin exposure are well known, and although there are suggestions in the literature of neurological effects persisting after the […]United States, National USA Chemical Weapons
Strides Made in Chemical Warfare Detection
Chemical black hole-based chemical warfare agent detector. Credit: University of Illinois Materials Research Laboratory. Sarin is a man-made nerve agent that can spread as a gas or liquid. According to the Center for Disease control, exposure to large doses will over-stimulate glands and muscles, and can lead to loss of consciousness or respiratory failure. Even […]United States, National USA Chemical Weapons