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Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes.
Excerpts: Apoptosis, characterized by nuclear fragmentation, chromatic condensation, and caspase activation, is a major molecular mechanism to eliminate cells (Oropesa-.vila et al. 2017 ). Apoptosis is observed widely in liver diseases (Cui et al. 2018 ; Potz et al. 2016 ). Fluoride, as an exogenous toxicant, has been reported to cause apoptosis in the liver […]
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Early diagnosis and complete recovery from fluorosis through practice of interventions
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Results and conclusions of the National Toxicology Program’s rodent carcinogenicity studies with sodium fluoride.
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Medical geology in tropical countries with special reference to Sri Lanka.
References Bhattacharya, P., Chatterjee, D., & Jacks, G. (1997). Occurrence of arsenic contaminated groundwater in alluvial aquifers from Delta Plains, Eastern India: options for safe drinking water supply. Water Resources Development, 13(1), 79–92. Article Google Scholar Christensen, H., & Dharmagunawardhane, H. A. (1986). Hydrogeological investigations in hardrock terrains of Sri Lanka with special emphasis on […]
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Rachitomimetic effects of fluoride feeding on the skeletal tissues of growing pigs
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Water treatment with silicofluorides and lead toxicity
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Histological and chemical studies in man on effects of fluoride
Comparison of fluoride content in the soft tissues of persons meeting the criteria of exposure to fluoride with the content in soft tissues of persons not meeting the criteria revealed no significant difference (P > 0.05). This finding indicates that fluoride is not stored in the soft tissues in significant quantities (table 3). The fluoride […]
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Human cultured IMR-32 neuronal-like and U87 glial-like cells have different patterns of toxicity under fluoride exposure.
When comparing the F-induced toxicity on neurons and glial cells, it is important to highlight that most studies have used neurons and only two have investigate de glial cells behavior after F exposure [21, 36]. The effect of F on neuronal cell viability is inconsistent across the studies with doses ranging from 18.09 ?g/mL to […]
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A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
Discussion … The increased precision using the average maternal U-F concentration as an indicator of prenatal fluoride exposure results in stronger statistical evidence of fluoride-associated deficits, compared with using cross-sectional or retrospective studies. Still, the amount of fluoride that reaches the brain during early brain development is unknown, and even the maternal U-F concentration measurements […]
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Topical fluoride as a cause of dental fluorosis in children.
Plain language summary Is the use of fluoride toothpaste during early childhood associated with discolouration/mottling of teeth? There is strong evidence that the use of toothpaste containing fluoride can prevent tooth decay (caries) in both children and adults. However, a possible adverse effect associated with the use of fluoride toothpaste is the mottling of permanent […]