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Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes
Results of previous studies have shown that fluoride has a higher and special affinity for calcium in bone tissue, which could result in osteofluorosis (19,20). It has been reported that osteofluorosis may increase the severity of osteoarthritis (OA) characterized by progressive degeneration of articular cartilage (21,22). Chondrocyte apoptosis may be involved in the onset and […]
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Rachitomimetic effects of fluoride feeding on the skeletal tissues of growing pigs
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Community water fluoridation and intelligence: prospective study in New Zealand
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Inorganic fluoride and functions of brain.
Note from the Fluoride Action Network: It’s worth noting that this review paper did not include these important Mother-Offspring studies: Bashash-2017, Valdez-Jimenez-2017, Green-2019. Nor did it include the ADHD study by Bashash-2018. Perhaps it was too late for the authors to have included the Green IQ study published in August 2019, the Riddell -October 2019 […]
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The Association between Community Water Fluoridation and Bone Diseases: A Natural Experiment in Cheongju, Korea.
Funding: This research was supported by a grant of the Division of Oral Health Policy, Ministry of Health and Welfare, Republic of Korea in 2014. References Community Water Fluoridation. Available online: https://www.cdc.gov/fluoridation/index.html (accessed on 10 March 2020). Ran, T.; Chattopadhyay, S.K. Community Preventive Services Task Force. Economic evaluation of community water fluoridation: A community guide […]
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Developmental neurotoxicity of fluoride: a quantitative risk analysis toward establishing a safe daily dose of fluoride for children
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Associations Between Prenatal Fluoride Exposure and Performance IQ in Canadian Preschool Aged Children: A Multilevel Modeling Approach.
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Fluoride exposure and duration and quality of sleep in a Canadian population-based sample.
Excerpts Introduction Inorganic fluoride can naturally occur in the environment or be introduced through industrial processes or fluoride supplementation programs. A primary method of fluoride supplementation is community water fluoridation, which refers to the practice of adding fluoridation chemicals to drinking water for the purpose of controlling dental caries. Ingestion of fluoridated drinking water is […]
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Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
References Lin E.P., Lee J.R., Lee C.S., Deng M., Loepke A.W. Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies. Neurotoxicol Teratol. 2017; 60: 117-128. PubMed Jevtovic-Todorovic V., Olney J.W. PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg. 2008; 106: 1659-1663. PubMed Loepke A.W. McGowan Jr., F.X. […]
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Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice.
1. Introduction Fluoride is a widespread environmental pollution, and groundwater is the major source of exposure in which the fluoride concentration can be as high as 35 ppm (Petrone et al., 2013). Fluorosis induced by geological origin is a serious public health concern in 28 nations particularly in India and China (Rafique et al., 2015). In […]