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Adverse Effects
Abstracts
NTIS
Reports
ACTIVITY:
Herbicide (dinitroaniline)
CAS Name:
2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine
Structure:
Adverse
Effects:
Adverse
Effects:
Anemia
Bladder
Blood
Body Weight Decrease
Bone
Cancer:
•
Possible Human Carcinogen - Urinary bladder, Kidney,
Thyroid, Non-Hodgkin's Lymphoma, Testicular
• Elevated odds ratio for
NON-HODGKIN'S
LYMPHOMA
among farmers
Dermal
Endocrine:
Suspected Disruptor
Endocrine: Testicular
Endocrine: Thyroid
Genotoxicity
Heart
Kidney
Liver
Reproductive |
Environmental
Effects:
Persists
in soil
PBT:
Persistent, Bioaccumulative and Toxic
Low
degradability, Bioaccumulative, and Toxic to water-living
organisms
Fish:
Highly toxic to Very highly toxic
Amphibians:
Slightly toxic to Highly Toxic |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
036101 |
California
Chemical Code |
597 |
US
Tolerances: |
151 |
FDA
LMS Code: |
CFR
180.207 |
Registered
use in
(includes only a limited list of countries)
|
Australia,
Canada, Finland, Germany, Hungary, India, Japan, New Zealand,
Portugal, South Africa, UK, US, Vietnam |
Japan's
Maximum Residue Levels (MRLs) |
Beans (dry), Broad beans, Hop, Other Legumes/pulses,
Other Potatoes, Peanuts (dry), Potato, Rice, Sugar beet, Sugarcane,
Sweet Potato, Taro, Yam,
Almond, Apple, Apricot, Artichoke, Asparagus,
Avocado, Banana, Barley, Blackberry, Blueberry, Broccoli, Brussel
Sprouts, Buckwheat, Burdock, Cabbage, Carrot, Cauliflower, Celery,
Cherry, Chestnut, Chicory, Corn, Cotton oil seeds, Craneberry,
Cucumber, Date, Eggplant, Endive, Garlic, Ginger, Ginkgo nut,
Grape, Grapefruit, Guava, Horseradish, Huckleberry, Kale, Kidney
beans, Kiwifruit, Komatsuna, Konjac, Kyona, Lemon, Lettuce,
Lime, Loquat, Makuwauri, Mango, Melons, Mitsuba, Multiplying
onion (inc. Shallot), Mushroom (Button, Shitake, Other), Natsudaidai
(whole), Nectarine, Okra, Onion, Orange, Oriental pickling melon,
Other Berries, Other Cereal grains, Other Citrus fruits, Other
Composite vegs,
Other Cucurbitaceous vegs,
Other Cruciferous vegs,
Other Liliaceous vegs,
Other Nuts, Other Oil seeds,
Other Solanaceous vegs,
Other Umbelliferous vegs,
Papaya, Parsley, Parsnip, Passion fruit, Peach, Pear, Peas,
Pecan, Persimon, Pimento, Pineapple, Plum, Pumpkin (inc Squash),
Quince, Radish, Rape oil seeds, Raspberry, Rye, Safflower oil
seeds, Salsify, Sesame oil seeds, Shungiku, Soybeans, Spinach,
Strawberry, Sunflower oil seeds, Tea, Tomato, Turnip (inc Rutabaga),
Unshu orange, Walnut, Watercress, Watermelon, Welsh (inc Leek),
Wheat |
US
Maximum Residue Levels permitted
in food commodities
|
Permitted
in or on 129 food commodities, including:
Alfalfa hay, Asparagus, Barley, Bean -mung,
Carrot, Corn, Cotton, Cress, Flax, Citrus fruit, Fruit (stone
crop Group 12), Grape, Hop, Legume (forage), Nut tree group,
Peanut, Peppermint, Rapeseed seed, Safflower seed, Sorghum,
Spearmint, Sugarcane cane, Sunflower seeds, Vegetable (Curcurbit
& Fruiting groups), Vegetable (leafy), Vegetable (root crop
exc. carrots), Vegetable (seed & pod), Wheat |
Other
Information |
Molecular
Formula: |
C13H16
F3 N3O4 |
Entry
Year: |
1959
First
registered in the US in 1963. |
Inventing
Company: |
Patented
by Eli Lily. |
Manufacturers: |
Dow
Agro
Makhteshim-Agan
Industria Prodotti Chimici
Tri Corporation
Albaugh Inc. |
Other
Names: |
L-36352
Treflan
Triflurex |
Manufacture
sites: |
ARGENTINA:
Atanor
AUSTRALIA: Nufarm
BRAZIL: Defensa
Industria de Defensivos
CHINA:
Zhejiang Dongyang Pesticide Factory
Dongyang
Kangfeng Organic Fluorine Chemicals Plant in
Dongyang City
(see
box below)
GUATEMALA: Agrotran
SA
HUNGARY: Budapest
Chemical Works
ISRAEL: Agan
Chemical
ITALY: Dintec
Agroquimica, Milan
ITALY: Industria
Prodotti Chimici, Milan
SOUTH AFRICA: Sanachem,
Canelands
US: Eli Lilly
(Dintec Agroquimica) Lafayette, Indianapolis 47902 |
Of
special interest: |
PAN
Data |
Material
Safety Data Sheets & Labels |
Jan
23, 2006: Conservation
Group Moves for Court Order Restricting Use of 66 Pesticides
in Core Red-Legged Frog Habitat.
San Francisco, Calif. – The Center for Biological Diversity
(CBD) in a legal motion today asked a U.S. District Court to
protect the threatened California red-legged frog (Rana aurora
draytonii) from 66 of the most toxic and persistent pesticides
authorized for use in California, by creating pesticide-free
buffer zones around the frog’s core habitat and by requiring
consumer hazard warnings so that all Californians may learn
how to protect frogs. [Trifluralin was
one of the 66 pesticides.]
In response to a lawsuit filed by CBD against the U.S. Environmental
Protection Agency (EPA) in April of 2002, the District Court
found in September of 2005 that the EPA violated the Endangered
Species Act (ESA) by registering pesticides for use without
considering how they might impact the continued existence of
the red-legged frog. The motion for “injunctive relief”
delivered today asks the court to protect the frog from pesticides
in or adjacent to aquatic frog habitat designated as core recovery
areas, until the EPA completes a formal consultation with the
U.S. Fish and Wildlife Service (USFWS) on the impacts of the
pesticides on red-legged frogs, as required under the ESA...
CBD is asking the Court to impose a three-year schedule for
the EPA to determine whether the 66 pesticides may affect the
red-legged frog and to complete formal consultations with USFWS
to ensure the pesticides are not jeopardizing the frog or contributing
to its decline. To minimize harm to frogs during the consultation
process, the motion asks for an injunction on use of the pesticides
around aquatic features and upland habitats within the frog’s
core recovery areas, as designated by USFWS in the agency’s
Recovery Plan for the California Red-legged Frog. This injunction
would also apply buffer areas for terrestrial and aerial pesticide
applications, affecting approximately 7 percent of the current
range of the frog and less than 1 percent of the area of California.
CBD is also requesting that the EPA conduct monitoring for pesticides
in three of the recovery areas to determine whether the buffers
are effectively protecting the frog, inform pesticide users
about the injunction, and post point-of-sale notifications warning
consumers about harmful effects these pesticides may have on
the frog... |
Oct
18, 2005 - Judge
orders EPA to notify retailers, distributors, about pesticide
concerns. By Peggy Andersen. Seattle
Post-Intelligencer. A federal judge has ordered the Environmental
Protection Agency to send letters to pesticide retailers, distributors
and wholesalers in three states (Washington, Oregon and California),
outlining their responsibilities for notifying consumers about
the dangers posed to salmon by the chemicals... At issue are
products containing Malathion, Carbaryl, Trifluralin
and Triclopyr, Diuron, 2,4-D and
Diazinon... |
July
12, 2005 (release date) - Initial risk assessment provided
by the rapporteur Member State of Greece for the existing
active substance Trifluralin. (208 pages). European Food Safety
Authority. Documents released:
-
Final
addendum to the Draft Assessment Report (DAR) (208 pages)
- Summary
(4 pages)
- Comments
on the draft assessment report (61 pages)
- Reporting
table (88 pages)
- EPCO expert
meeting reports (131 pages)
- Evaluation
table (61 pages)
|
March
14, 2005 - European Food Safety Authority: Conclusion regarding
the peer review of the pesticide risk assessment of the active
substance trifluralin. EFSA
Scientific Report (2005) 28, 1-77. (77 pages)
Note: See page 30 for the list
of studies to be generated or still ongoining. |
March
14, 2005 - European Food Safety Authority: Summary
of the EFSA Scientific Report (2005) 28, 1-77. (4 pages) |
Online
August 2005 - UK Environmental Agency. Table
2: List 2 Dangerous substances. Table 2a: Environmental Quality
Standards (EQS) for List 2 dangerous substances, EC Dangerous
Substances Directive (76/464/EEC). List
2 substances include Cyfluthrin, Flucofuron, Trifluralin.
Also at this primary
site. |
November
24, 2004 - US EPA documents released:
•
August 30, 2004 - Trifluralin
Risk Assessment Overview (10 pages)
•
May
7, 2004 - Trifluralin:
Human Health Risk Assessment (55 pages)
•
October
2, 2003 - Toxicology
Disciplinary Chapter for the Tolerance Reassessment Eligibility
Decision Document Trifluralin (PC Code: 036101)
(66 pages)
•
August
31, 2004 - Report
of the Food Quality Protection Act (FQPA) Tolerance Reassessment
Progress and Risk Management Decision (TRED) for Trifluralin
(3 pages)
•
Sept
21, 2004 - Clarification
of the Trifluralin Drinking Water Assessment for the HED
Tolerance Reassessment and Characterization on Relative
Differences for USGS NAWQA Ground Water Monitoring Data
and Its Comparison to SCI-GROW Model Predictions
as presented in the NRDC objection (Imidacloprid
FR) and the trifluralin TRED (D308490) (2 pages)
•
May
12, 2004 -
Review of "Dissipation of Transferable Residues of
Benefin and Trifluralin on Turf Treated with a Formulation
of the Pesticides" (15 pages)
•
May
2, 2003 - Report
of the Hazard Identification Assessment Review Committee -
Trifluralin (P.C. Code 036101) - (32 pages)
•
May
5, 2004 - Residential
Exposure Assessment and Recommendations for the Tolerance
Reassessment Evaluation Decision (TRED) Document for
Trifluralin (50 pages)
•
March
8, 2004 - Trifluralin.
Anticipated Residues, Acute, Probabilistic, Chronic and
Cancer Dietary Exposure Assessments for the Reregistration
Eligibility Decision (68 pages)
•
March
9, 2004 - Trifluralin:
Health Effects Division (HED) Metabolism Assessment Review
Committee (MARC) Decision Document. Meeting Date: 4
February 2004. PC Code: 036101 (4 pages)
•
March
4, 2004 - Trifluralin:
Residue Chemistry Chapter for the Tolerance Reassessment
Evaluation Decision (TRED) Document (75 pages)
•
Dec
3, 2003 - Trifluralin
- Drinking Water Assessment for Tolerance Reassessment Eligibility
Decision (PC Code: 036101; DP Barcode: D296624 (109
pages)
•
March
9, 2004 -
Review of Trifluralin Incident Reports DP Barcode D300064,
Chemical# 036101 (11 pages)
|
April
1996 -
Reregistration Eligibility
Decision (RED) - US EPA |
April
1996 -
R.E.D. FACTS -
Environmental Protection Agency |
TOXNET
profile from Hazardous Substances Data Bank |
1993
- IRIS
profile - US EPA |
June
2002 - In
Australia when Trifluralin is used "{T} To prevent root
intrusion in underground orchard irrigation systems"
no maximum residue levels are required.
Ref: June 2002. Table 5. Uses of substances where
maximum residue limits are not necessary. Australian National
Registration Authority for Agricultural Veterinary Chemicals.
The MRL Standard. Maximum residue limits in food and animal
feedstuff. http://www.nra.gov.au/residues/mrl5.pdf
|
2000
US Toxic Release Inventory: Brief Summary |
2000
Toxics Release Inventory (TRI). On-site
and Off-site Reported Releases (in pounds), All Facilities (of
31) for facilities in All Industries, Trifluralin (list 1988,
threshold changed to 100 lbs in 2000). |
US
Map of Pesticide Use: 1992-1995 |
Herbicide
Products - partial list |
April
2002 -
Beer in the UK: 23 organofluorine
pesticides approved for use on malting barley. Published
by the British Beer and Pubs Association and Brewing Research
International. |
Abstracts |
FAN's
compilation of reports
(with abstracts) available from
The National Technical Information
Service (NTIS) |
UK:
Table 2. Dangerous Substances Directive.
List 2 substances include Cyfluthrin, Flucofuron, Trifluralin. |
Fact
sheet from Pesticides News (UK) |
December
6. 2001 -
CERCLA Priority List of Hazardous
Substances. The Comprehensive Environmental
Response, Compensation, and Liability Act (CERCLA) section 104
(i), as amended by the Superfund Amendments and Reauthorization
Act (SARA), requires ATSDR and the EPA to prepare a list, in
order of priority, of substances that are most commonly found
at facilities on the National Priorities List (NPL) and which
are determined to pose the most significant potential threat
to human health due to their known or suspected toxicity and
potential for human exposure at these NPL sites. |
March
2000 - Cenex Supply and Marketing, Inc. (CSMI) in Quincy, Grant
County, Washington, operated a liquid fertilizer and soil fumigant
storage and distribution facility. Seious contamination resulted
from the landspreading of pesticide sediment sludges on agricultural
land. Among the many pesticides found in soil samples, three
herbicides (trifluralin,
vernolate, and ethalfluralin), one insecticide
(chlorpyrifos), one pesticide (disulfoton), and three metals
(chromium, beryllium, and cadmium) exceeded one or more health-based
comparison values in CSMI soil. The population of Quincy is
3,715. This report characterizes the community's concerns about
excess cancer and disease rates, very rare abnormalities such
as Rubinstein-Taybi
Syndrome, and ill health as not "unusual"
- a typical ATSDR-explantion handed out to very sick communities. |
February
2000 -
Hungary's Pesticide
Industry produces the fluorinated pesticides:
Benefin (Benfluralin); Flufenzin; Fluometuron; Trifluralin.
Hungary's pesticide industry includes partnerships with DuPont,
Rhone Poulenc, and the American CEDAR group. Hungary's Ministry
of Economic Affairs. |
June
1996 -
Pesticide
Information Profile - Cornell Extoxnet |
1996
-
Material Safety Data
Sheet for Treflan HFP Herbicide. 43% Trifluralin - DOW
AGRO SCIENCES |
November
1995 -
Pesticide Fact Sheet - Information Ventures, Prepared for
the U.S. Department of Agriculture, Forest Service by Information
Ventures, Inc. |
1995,
Updated
Summary of Toxicology Data, California EPA |
Hazard
Summary - US EPA Office
of Air Quality Planning & Standards |
One
of 8 fluorinated pesticides used to cultivate grapes in Australia. |
1990
- 1993:
Cotton
pesticide usage in the US, 1990-1993 -
USGS.
Trifluralin (# 2); Fluometuron (#3); Norflurazon (# 9) |
1978
-
Bioassay
of Trifluralin for Possible Carcinogenicity -
National Toxicology Program |
2000
-
"P" is for Poison.
Update on Pesticide Use in California Schools, by
TM Olle. A report by Californians for Pesticide Reform. |
US
EPA Index of Cleared Science Reviews - (see also NTIS
Reports) |
1991
- International
Agency for Research on Cancer (IARC) |
June
14, 2001 - Implementation
of the Community Strategy for Endocrine Disruptors - a
range of substances suspected of interfering with the hormone
systems of humans and wildlife. Communication from the Commission
to the Council and the European Parliament. Commission of
the European Communities, Brussels COM (2001) 262 final. (More
information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm
)
This
document presents a "priority list of substances for
further evaluation of their role in endocrine disruption.
During 2000, a candidate list of 553 man-made substances and
9 synthetic/natural hormones has been identified." Organofluorine
pesticides in this list include: |
Substances
included on the Endocrine Disruptor Liist |
CAS
No. |
Substances
included on the Endocrine Disruptor Liist |
CAS
No. |
Bifenthrin |
82657-04-3
|
Flutriafol |
76674-21-0 |
Cyhalothrin
(@Karate) |
91465-08-6 |
Fluvalinate |
69409-94-5 |
Diflubenzuron |
35367-38-5 |
Prodiamine |
29091-21-2 |
Epoxiconazole |
- |
Stannane,
tributylfluoro [Tributyltin fluoride] |
1983-10-4 |
Fipronil |
- |
Trifluralin |
1582-09-8 |
Fluazifop-butyl |
69806-50-4
|
|
|
Dongyang
Kangfeng Organic Fluorine Chemical Factory
Dongyang Kangfeng Organic Fluorine Chemicals Plant was established
in 1995, it’s a key enterprise for production and
development of organic fluorine series products, which is
one of the hundred tax-payers in Dongyang City. Now, the
plant has a fixed asset of more than USD 500 million, a
working staff of 81 persons including 18 researchers, and
contains more than 20,000 square meters, and has established
a good cooperation with some chemical research institutes
all over the world.
Our plant is located in Xueshi Zai Industrial Zone of Huailu
Dongyang city, which is in the middle
of Zhejiang province P.R. China where is abundant of fluorine
ore. We have a strong technology research group,
advanced production technicals and first class production
equipments, a perfect quality control system and advantageous
location. We have established a set of environmental protection
system. At present, our annual production of benzotrifluoride,
p-chlorobenzotrifluoride and their series products are over
10,000 tons including Herbicides-Trifluralin
and Benefin technical with 4,000 tons
1,000 tons respectively. They are of good quality and are
mainly sold abroad.
We are sticking to the principle of leading by science and
technology, depending on products' good quality and developing
on good credit and keep our efforts in deep development
of trifluoromethyl series, fluobenzene series medicine and
pesticide, dyeing staff intermediates...
Online as of April 17, 2005, at
http://www.kangfeng.com/pages/about.htm
|
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
Date
Published |
Docket
Identification Number |
Details |
November 8, 2006 |
EPA-HQ-OPP-2006-0084 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain
Pesticide Registrations.
EPA Registration no. |
Product
Name |
Registrant
|
000228-00207 |
Riverdale Team .87 Lawn Weed and Feed |
Nufarm Americas Inc.
150 Harvester Drive Suite 200,
Burr Ridge IL 60527 |
000228-00256 |
Riverdale Team 1.33% Lawn Weed and Feed |
same |
009198-00091 |
The Andersons Tee Time Plus 0.57% Team |
The Andersons Lawn Fertilizer
Division, Inc., dba/ Free Flow
Fertilizer,
PO Box 119,
Maumee OH 43537 |
009198-00091 |
The Andersons Tee Time Plus 0.57% Team |
same |
009198-00101 |
The Andersons Fertilizer with 0.87% Team |
same |
009198-00130 |
The Andersons Fertilizer with 1.50% Team |
same |
010404-00056 |
Lesco Turf Fertilizer with 1.15% Team
|
Lesco Inc.,
1301 E. 9th Street,
Suite 1300, Cleveland OH
44114-1849 |
|
September 15, 2006 |
EPA-HQ-OPP-2005-0459 |
Tolerance
Actions. FINAL
RULE.
EPA is revoking certain tolerances for the herbicide trifluralin;
and modifying certain tolerances for the herbicides sodium acifluorfen
and trifluralin. In addition, EPA is establishing new tolerances
for the herbicide trifluralin. The regulatory actions in this
document are part of the Agency's reregistration program under
the FIFRA. |
September 1, 2006 |
EPA-HQ-OPP-2006-0702 |
Request
for Public Comment on Proposed Stipulated Injunction Involving
66 Pesticides and the California Red-legged Frog.
Center for Biological
Diversity vs EPA. |
June 28, 2006 |
EPA-HQ-OPP-2006-0084 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
EPA Registration no. |
Product
Name |
Registrant
|
008660-00019
|
Sta-Green Crabgrass
Preventer Plus
Lawn Fertilizer |
United Industries Corp. d/b/a
Sylorr Plant Corp.
PO Box 142642
St. Lou, MO 631140642. |
008660-00143
|
Vertagreen Fertilizer for Professional
Use with Team |
same |
008660-00149
|
Vertagreen Lawn Food with Crabgrass Control |
same |
008660-00151
|
Vertagreen for Professional Turf with
Team |
same |
032802-00024
|
Excel-N-Plus W/ crabgrass Control + Lawn
Food |
Howard Johnson's Enterprises Inc.
700 W. Virginia St
Ste 222,
Milwauk, WI 532041548. |
032802-00033
|
Hi-Tech Crabgrass Control |
same |
032802-00035
|
Lawn Service Crabgrass Control |
same |
032802-00040
|
Proteck 58 |
same |
|
Nov
4, 2005 |
OPP-2005-0288 |
Notice
of Receipt of Request for Amendments to Delete Uses in Certain
Pesticide Registrations.
EPA Registration no. |
Product
Name |
Delete
from Label |
Registrant
Requesting Amendments to Delete Uses |
001386-00609
|
Trifluralin
4 EC Herbicide |
Eggplant
and Lentils |
Universal
Cooperatives Inc.
1300 Corporate Center
Curve, Eagan, MN 55121. |
|
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
|
|