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The National Toxicology Program

This section is dedicated to the National Toxicology Program’s (NTP) long involvement with the issue of fluoride's toxicity. The NTP is the scientific research arm for U.S. regulatory agencies. It comes under the aegis of the National Institute of Environmental Health Sciences (NIEHS). The NIEHS, in turn, comes under the umbrella of the National Institutes of Health (NIH). -Updated May 2, 2023 (EC).

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NTP 1990 – 2021: Submissions to NTP and/or NAS

Year	Submissions to NTP and/or NAS on Fluoride’s Neurotoxicity
	ALSO LOOK AT https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/fluoride/index.html#background
2020	October 19, 2020. Submission from Chris Neurath on behalf of FAN to the National Academies Committee to Review the Revised National Toxicology Program’s Monograph on Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. LINK: http://fluoridealert.org/wp-content/uploads/ntp.neurath.submission-to-nas-on-revised-ntp-monograph.10-19-20.pdf
2020	October 19, 2020. Outline with figures of submission from Chris Neurath on behalf of FAN to the National Academies Committee to Review the Revised National Toxicology Program’s Monograph on Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. *LINK:* http://fluoridealert.org/wp-content/uploads/ntp.neurath.outline-with-figures-of-submission-to-nas.10-19-20.pdf
2020	October 19, 2020. Oral comments from Chris Neurth on behalf of FAN on the NTP’s Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects to the National Academies Committee to Review the Revised National Toxicology Program’s Monograph. LINK: http://fluoridealert.org/wp-content/uploads/ntp.neurath-oral-comments-to-nas.10-19-20.pdf
2020	October 19, 2020. Comments from Paul Connett of FAN to the National Academies Committee to Review the Revised National Toxicology Program’s Monograph on Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. *LINK:* http://fluoridealert.org/wp-content/uploads/ntp.paul-connett.comments-to-nas.10-19-20.corrected-1.pdf
2020	October 16, 2020. Comments submitted from the American Dental Association to the National Academies on the “Revised NTP Monograph on Fluoride Exposure and Neurodevelopmental and Cognitive Health. LINK: http://fluoridealert.org/wp-content/uploads/ntp.ada_.comments.10-16-20.pdf
2019	November 6, 2019. Oral presentation by Chris Neurath, of the Fluoride Action Network, to NAS committee reviewing the NTP’s draft report (plus additional comments) Figures used by Chris Neurath in his presentation to the NAS (above)
2019	November 19, 2019. Comments to NTP from the American Dental Association on the Draft Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.
2016	July 8, 2016. Comments Regarding the NIH National Toxicology Program’s Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies. By Lorena Espinoza, DDS, MPH, Associate Director for Science, Division of Oral Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention.
2016	January 8, 2016. Submission on the sensitivity to fluoride: rodents vs humans. By Michael Connett and Chris Neurath, Fluoride Action Network.
2016	January 8, 2016. Submission to the National Toxicology Program’s review of fluoride as a carcinogen. By Michael Connett and Chris Neurath, Fluoride Action Network. • Appendix 1C. Submission from FAN to the National Research Council Committee: Toxicologic Risk of Fluoride in Drinking Water; BEST-K-02-05-A. Originally submitted to NRC on March 30, 2005. • Appendix 2. FAN submission to NRC 2006 on cancer [Grandjean 2004]. Originally submitted to NRC on Mary 27, 2004. Submitted to NTP on January 8, 2016. • Appendix 3. Kenya study abstract [Neurath 2005a]. Correlation between the incidence of dental fluorosis and osteosarcoma in provinces of Kenya. • Appendix 4. Kenya study of fluoride and osteosarcoma in Kenya [Neurath 2005b]. Introduction and full study. • Appendix 5. Thiessen submission to California Office of Environmental Health Hazard Assessment, July 2011. • Appendix 6-A. Review of Kim et al. (2011) & Comparison to Bassin et al. (2006). • Appendix 7A. Review of Gelberg 1994, 1995 for NTP. • Appendix 8-A. Review of Blakey/McNally 2014 fluoride--osteosarcoma ecological study Great Britain. • Appendix 9. Comber 2011 Ireland osteosarcoma-F study review for NTP cancer review. • Appendix 10A. Review of Young 2015 F-osteosarcoma ecological study. • Appendix 11. Review of Levy 2012 F-osteosarcoma ecological study USA.
2015	January 15, 2015. Submission to the NTP from the American Dental Association in response to their “Request for Information on Nominated Topics—Fluoride”
2015	November 6, 2015. FAN’s submission in response to solicitation for comments in the Oct 7, 2015 Federal Register.
2015	November 30, 2015. Submission on developmental neurotoxicity. By Michael Connett, Fluoride Action Network.
1990	May 1, 1990. Marcus W. Memorandum from William L. Marcus, Ph.D., Senior Science Advisor, Criteria & Standards Division Office of Drinking Water, to Alan B. Hais, Acting Director . Subject: Fluoride Conference to Review the NP Draft Fluoride Report. US EPA. May 1.

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