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The National Toxicology Program

This section is dedicated to the National Toxicology Program’s (NTP) long involvement with the issue of fluoride's toxicity. The NTP is the scientific research arm for U.S. regulatory agencies. It comes under the aegis of the National Institute of Environmental Health Sciences (NIEHS). The NIEHS, in turn, comes under the umbrella of the National Institutes of Health (NIH). -Updated May 2, 2023 (EC).

NTP: Publicly Available Documents on Fluoride

If there are documents that should be included in this list, please email them to us. Thanks

Year

Documents on Fluoride’s Toxicity
NTP: National Toxicology Program
NASEM: National Academies of Sciences, Engineering and Medicine
2023 NTP. April. NTP Board of Scientific Counselors Working Group Report on the Draft State of the Science Monograph and the Draft Meta-Analysis Manuscript on Fluoride. 726 pages.
2023 NTP. Documents Provided to the NTP Board of Scientific Counselors (BSC)
and BSC Working Group (1,573 pages).

PAGE 1. DRAFT NTP Monograph on the State of the Science Concerning Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Systematic Review (September 2022 version)

PAGE 291. Reviewers’ Comments and NTP Authors’ Responses on the DRAFT State of the Science Monograph

PAGE 465. DRAFT Meta-Analysis Manuscript (July 2022 version)

PAGE 503. DRAFT Meta-Analysis Manuscript – Supplemental Materials (July 2022 version)

PAGE 567. Reviewers’ Comments and NTP Authors’ Responses on the DRAFT Meta-Analysis Manuscript

PAGE 656. DRAFT NTP Monograph on the State of the Science Concerning Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Systematic Review (May 2022 Version)

PAGE 944. DRAFT NTP Monograph on the State of the Science Concerning Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Systematic Review (May 2022 Version)

PAGE 1195. DRAFT NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects (September 16, 2020 Version)

PAGE 1515. DRAFT NIEHS/DNTP Response to the Review of the Revised NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Letter Report (NASEM Comments on the State of Science Monograph)

PAGE 1554. DRAFT NIEHS/NTP Response to the Review of the Revised NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Letter Report (NASEM Comments on the Meta-Analysis Manuscript)
2021 NTP. Feb 9, 2021.  Private statement on shutting down its systematic review on fluoride’s neurotoxicity
2021 NASEM. Feb 9, 2021. The peer-revierw of NTP’s Revised Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Letter Report.
2021 NASEM. Feb 9, 2021. News Release: National Academies completes review of National Toxicology Program’s Second Draft Monograph on Fluoride Exposure and Neurodevelopmental and Cognitive Effects.
2020 NTP. Sept 16, 2020.  Draft Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects*.
2020 NASEM. Sept 16, 2020. Committee on Peer Review of the NTP Monograph on Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.
LINK: http://fluoridealert.org/wp-content/uploads/ntp.nasem-committee-to-review.fluoride.2020.pdf
2020 NTP. Sept 16, 2020. Protocol for the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. Project Leader: Kyla Taylor, PhD.
LINK: http://fluoridealert.org/wp-content/uploads/ntp-f-protocol_revised.sept-16-2020.pdf
2020 NTP. Sept 16, 2020. Literature Search Results for the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. 
LINK: http://fluoridealert.org/wp-content/uploads/ntp.literature-search.9-16-20.pdf
2020 NASEM. March 5, 2020. Review of the Draft NTP Monograph: Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects (2020). National Academy of Sciences, Engineering and Medicine.
LINK:  http://fluoridealert.org/wp-content/uploads/nas-review-of-ntp-review.march-5-2020.pdf
2019 NTP. Oct 22, 2019.  Draft Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. National Toxicology Program. Dated September 6, 2019; available October 22, 2019.
LINK: http://fluoridealert.org/wp-content/uploads/2019.ntp_.draft-fluoride-systematic-review.online-Oct-22.pdf
2019 NTP-NIEHS. Nov 6, 2019. Presentation to the National Academies on the draft NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects, by Kyla W. Taylor, PhD, Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences. November 6.
LINK: http://fluoridealert.org/wp-content/uploads/taylor.presentation-on-ntp-draft-monograph-to-NAS.nov-6-2019.pdf
2017 NTP. June. Protocol for Systematic Review of Effects of Fluoride Exposure on Neurodevelopment.
2016 NTP. July. Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies. NTP Research Report 1. National Toxicology Program.
2015 NTP.. Dec 2. Evaluation of Fluoride Exposure and Potential for Developmental Neurobehavioral Effects. By Kristina Thayer, PhD, Office of Health Assessment
and Translation (OHAT), NIEHS, to the NTP’s Board of Scientific Counselors (see below).
2015 NTP. Dec 1-2, 2015.NTP’s minutes of a 2-day meeting with their Board of Scientific Counselors. Discussion was on NTP’s Evaluation of Fluoride Exposure and Potential for Developmental Neurobehavoral Effects.
2015 NTP. Oct 7. Recommendation to review fluoride as a carcinogen, developmental toxicant, and endocrine disruptor. Federal Register. Notice.
1998 NTP. Final Background document for Vinyl Fluoride. 8th Report on Carcinogens.
1990

STUDY BY NTP

Toxicology and Carcinogenesis Studies of Sodium Fluoride in F344/N Rats and B6C3f1 Mice. Technical report Series No. 393. NIH Publ. No 91-2848. National Institute of Environmental Health Sciences, Research Triangle Park, N.C.
1990

STUDY ABSTRACT by NTP
1990

April 26.
STUDY: TRANSCRIPT.
Volume 1, pages 1 – 2512.

NTP: Peer Review of Draft Technical Report of Long-Term Toxicology and Carcinogenesis Studies and Toxicity Study, Sodium Fluoride; Research Triangle Park, North Carolina.
1990

STUDY: Pathology Tables – Rats. NTP:
1990

STUDY: Pathology Tables – Mice. NTP:
1990

STUDY: Growth and Survival Curves – Rats. NTP:
1990

STUDY: Growth and Survival Curves – Mice. NTP:
1990

STUDY: Target Organs and Levels of Evidence for TR-393 – NTP:
1990 About/Findings

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