In 2015, the NTP solicited a request for information in the Federal Register on October 7 on fluoride’s Carcinogenicity, Developmental Neurotoxicity and Endocrine Disruption. The Fluoride Action Network (FAN) submitted comments (see below) and the NTP made the decision to investigate fluoride’s neurotoxicity.
On December 2, 2015, an Evaluation of Fluoride Exposure and Potential for Developmental Neurobehavioral Effects was presented by Kristina Thayer, PhD, of the Office of Health Assessment and Translation (OHAT), NIEHS.
In July 2016, the NTP released its Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies. Research Report 1.
In 2016, the NTP began a “systematic review” of fluoride’s neurotoxicity in humans. This was the first time that any government undertook this task. The draft review took three years and the first draft was released in 2019.
In June 2017 , the NTP’s Office of Health Assessment and Translation released its Protocol for Systematic Review of Effects of Fluoride Exposure on Neurodevelopment.
Submissions to the National Toxicology Program
from Michael Connett and Chris Neurath
In response to NTP’s request for information on fluoride’s carcinogenicity, developmental neurotoxicity and endocrine disruption, the following submissions were submitted from Connett and Neurath on behalf of FAN.
Developmental Neurotoxicity and Endocrine Disruption.
• November 30, 2015. Submission on developmental neurotoxicity and endocrine disruption. Michael Connett.
Comparative sensitivity to fluoride: rodents vs humans
• January 8, 2016. Submission on the sensitivity to fluoride: rodents vs humans. Connett & Neurath.
• Appendix 6-A. Review of Kim et al. (2011) & Comparison to Bassin et al. (2006).
• Appendix 7A. Review of Gelberg 1994, 1995 for NTP.
• Appendix 10A. Review of Young 2015 F-osteosarcoma ecological study.
• Appendix 11. Review of Levy 2012 F-osteosarcoma ecological study USA.