Abstract

In previous studies we investigated the impact of subchronic exposure of rats to sodium fluoride administered in their drinking water as it affected selected biochemical parameters in their soft tissues and organs. The activity of glutathione peroxidase and the concentrations of fluoride, reduced glutathione (GSH), substances reacting with thiobarbituric acid (TBARS), and carbonyl groups were determined in kidney, liver, brain, testis, and blood or serum. To ascertain if there is interdependence between fluoride concentrations and these free radical parameters, respective correlation coefficients were calculated. Strong positive and negative correlations in the tissues investigated were found. The results of this study increase the evidence for free radical involvement in fluoride toxicity.

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