Abstract
Based on evidence that fluoride ion (F) increases the production of reactive oxygen species, inhibits antioxidant enzyme activity, and enhances lipid peroxidation, a study of these effects was conducted on 52 patients with chronic renal failure (CRF), of whom 33 were under going chronic haemodialysis (HD) with the use of polysulphone membrane dialysers, while 19 with less advanced CRF, who were not undergoing HD, were treated conservatively with angiotensin-converting enzyme inhibitors and diuretics. Serum concentrations of F, Cu, Zn, Se, and thiobarbituric acid reactive substances (TBARS), along with serum activity levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured. Although serum F levels were higher both before (p<0.001) and after (p<0.002) HD than in the conservatively treated group, HD resulted in a statistically significant (p<0.005) decrease of the F level. In both patient groups, a positive correlation was found between the levels of serum F and TBARS. In patients undergoing HD, a negative correlation was observed between the serum F level before HD and SOD activity (p<0.01) on the one hand and copper levels (p<0.0004) on the other. In the conservatively treated patients not undergoing HD, the GPx activity level in the serum was positively correlated with the F level. Thus an oxidation promoting action of F in patients with CRF was confirmed
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The effect of hemodialysis upon serum levels of fluoride
Serum and dialysate ionic fluoride (F-) were determined in 29 patients under hemodialysis (HD) treatment. Serum creatinine (Cr), blood urea nitrogen (BUN) and phosphorus (P) were also examined before and after HD in 92 patients including the above 29 patients under the same treatment. Results reveal that serum F- levels
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Effects of dialysate calcium and fluoride on bone disease during regular hemodialysis
A previous study indicated that, in patients maintained by hemodialysis, clinically and roentgenographically apparent bone disease appeared almost exclusively when the dialystate calcium concentration was less than 5.7 mg per 100 ml. In the present study, bone biopsy specimens from the iliac crest were studied at the beginning and end
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Exposure to excessive fluoride during hemodialysis.
The safety of fluoridated community water supplies for dialysate and long-term intermittent hemodialysis has been questioned since 1965 [1]. The only significant means of clearing fluoride from body fluids are renal excretion and incorporation into bone [2]. When dialysate is prepared with fluoridated water, fluoride ion moves along a concentration
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An outbreak of fatal fluoride intoxication in a long-term hemodialysis unit
OBJECTIVE: To determine the cause of an outbreak of acute illness and death in a long-term hemodialysis unit. DESIGN: A retrospective cohort and case-control study of patients receiving hemodialysis and a laboratory study of a model deionization system to purify water for hemodialysis. SETTING: An outpatient hemodialysis unit of a university hospital. PATIENTS:
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Bone fluoride in patients with uremia maintained by chronic hemodialysis
Bone specimens from 42 patients with end-stage renal disease and from 9 patients without renal or bone disease have been analyzed for the content of fluoride, calcium, and phosphorus. Thirty-one patients were treated with chronic hemodialysis for periods ranging up to 56 months by employing dialysate made up with tap
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Fluoride & Osteomalacia
One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid content of bone. Osteoid is unmineralized bone tissue. When bones have too much of it, they become soft and prone to fracture -- a condition known as osteomalacia. As shown below, fluoride has repeatedly been
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
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Annapolis: Water Fluoridation Linked to Death of Dialysis Patient
EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoridation, Dialysis & Osteomalacia
In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on
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