Abstract
In this study, our objective was to determine blood T3, T4, and TSH levels in rabbits, which were administered fluoride chronically. Twenty one male rabbits were divided into three groups. The rabbits in group I (control), group II and III were administered, respectively, normal drinking water (containing 0.07 ppm fluoride), drinking water containing 10 ppm fluoride and water containing 40 ppm fluoride for 70 days. On the days 21 and 70 blood was taken and plasma T3, T4, TSH and fluoride levels were studied. According to the results obtained a statistically significant increase was observed in the T3 level of the rabbits receiving fluoride at 40 ppm level for 70 days compared with controls, and a statistically significant decrease was detected inT4 level. Plasma fluoride level increased in proportion to the amount and duration of the fluoride administered.
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Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level.
To assess the roles of dietary protein (Pr) and calcium (Ca) level associated with excessive fluoride (F) intake and the impact of dietary Pr, Ca, and F on thyroid function, 144 30-day-old Wistar albino rats were randomly allotted to six groups of 24 (female:male = 1:1). The six groups were
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Effects of high fluoride and low iodine on thyroid function in offspring rats
Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water (45 mg F- L-1 from 100 mg NaF L-1), low dietary iodine (0.0855 mg kg-1), or both together in order to
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[An investigation on the serum thyroid hormones and fluoride concentrations in patients with endemic fluorosis].
Endemic fluorosis is a systematic disease. We investigated the serum free fluoride, thyroid hormones and TSH concentrations in 37 cases. Significantly lowered serum T4 and T3 and increased TSH were found in patients. Patients' serum rT3 concentrations were not significantly different from the controls. Significant negative correlations were found between
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[Chronic effects of fluorides on the pituitary-thyroid system in industrial workers].
Radioimmunologic study of thyrotropin and thyroid hormones in the blood of those engaged in fluorine production showed moderate functional changes of the hypophysis-thyroid gland system, not accompanied by clinical manifestations of hypo- or hyperthyreosis and caused by disorders of the regulatory chain and fluorine impact on thyroid hormones' metabolism at
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Analysis of the protective effects of y-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.
CONTEXT: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, y-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. OBJECTIVE: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
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