Abstract
Soft tissue fluoride toxicity is well established. Several animal and human studies of the effect of fluoride on the thyroid gland have shown conflicting results. Endemic fluorosis and goitre are widespread in India with considerable overlapping in different geographical zones. We examined 22,276 individuals for presence of goitre and dental fluorosis and estimated the fluoride and iodine content of their drinking water. Overall goitre and dental fluorosis prevalences were 14.0% and 12.2%, respectively, and were significantly and positively correlated. No significant relationship was observed between water iodine level and goitre. In the study area only 0.3% of cases were visible goitre (Grade-II and above) and all goitre cases were euthyroid. This suggests that fluoride-induced goitres are brought about by anatomical or structural changes rather than functional changes.
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[Incidence of goiter in pubertal girls of the Piotrków Region and the iodide content in drinking water].
No abstract available
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Endemic Goitre in the Union of South Africa and Some Neighbouring Territories.
Authors: Douw G. Steyn, B.Sc., Dr. Med. Vet. (Vienna), D.V.Sc., Professor of Pharmacology, Medical Faculty, University of Pretoria; J. Kieser, Artseksamen (M.D.), former Chief Medical Inspector of Schools, Transvaal Provincial Administration; W.A. Odendaal, D.Sc., Research Officer in Nutrition, Union Department of Nutrition, Pretoria; H. Malherbe, M.A., M.B.Ch.B., Senior Medical Officer, Poliomyelitis Research Foundation, South
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Functional state of thyroid under extended exposure to fluorides
The issue of specific effect of fluorine on the thyroid in humans remains debatable. There is no doubt, however, that cases of experimental fluorosis are characterized by specific toxicity of fluorine to the thyroid. The hypoactivity of thyroid epithelium is observed, the destructive changes in the follicular cells increasing with the
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Goitre in school girls of the Mewat area of Haryana
A survey was carried out on 5449 school girls aged 10-16 years in the Mewat area of Haryana for goitre. The overall prevalence of goitre was nearly 29.5%. Thus goitre was a public health problem in the region. Analysis of the water sources in the study population used for drinking
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A survey of goiter morbidity in Ban Mae Toen, northwest Thailand.
A number of cases of goiter have been reported from Ban Mae Toen (BMT) northwestern Thailand, therefore we carried out this study to evaluate the prevalence and severity of goiter in BMT. We suspected fluoride toxicity as a factor in this phenomenon, therefore we used a WHO model using photographs
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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