Abstract

Intravenous infusion of 6 mg of fluoride/kg/hr for 3 hr caused a sharp decrease in formation of respiratory ¹⁴CO₂ from [¹⁴C]glucose, regardless of position of the label. Oxidation of [1-¹⁴C]fructose was not impaired, indicating that triose metabolism was not hindered; this information, along with the similarity in depression of metabolism of all labels indicated that glycolysis was not impaired. Glycogen deposition was decreased. The data suggest that the interference caused by fluoride at the observed concentrations is located at or prior to phosphorylation of glucose.

• Related Studies :

  • Clinical study of effect of high fluoride on the function of the pancreatic islet’s B cells.

    Objective: To study the effect of excessive fluoride intake on the function of pancreatic islet’s B cells. Methods: We performed x-rays, determined the [F] in the urine, conducted OGTT insulin and C-peptide releasing tests in the serum, and analyzed the drinking water quality of the exposed group and control group. Results: (1)

  • The pathogenesis of endemic fluorosis: Research progress in the last 5 years.

    Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long-term direct

  • Effects of fluoride on insulin signaling and bone metabolism in ovariectomized rats

    Fluoride is an essential trace element for the maintenance of bone health owing to its capacity to stimulate proliferation and osteoblastic activity that can lead to increased bone formation. However, excessive sodium fluoride (NaF) intake can impair carbohydrate metabolism thereby promoting hyperglycemia, insulin resistance, and changes in insulin signaling. Thus,

  • Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations

    OBJECTIVES:  Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and

  • Inorganic plasma fluoride concentrations and its renal excretion in certain physiological and pathological conditions in man

    In a study involving 2200 patients the inorganic plasma fluoride concentration (IPFC) increased with increasing age. In a fluoridated (1 ppm) community this increase was more pronounced than in a low fluoride (0.2 ppm) community. The mean renal clearance of fluoride and the daily amounts excreted also increased slightly until

• Related FAN Content :

  • Fluoride & Impaired Glucose Tolerance

    The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs

  • NRC (2006): Fluoride's Effect on Glucose Metabolism

     This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific

  • Fluoride Sensitivity Among Diabetics

     This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions

  • Fluoride & Insulin

    Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics

  • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus

    This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In