Abstract
Rats given sodium fluoride at 10 mg/kg daily by the intraperitoneal route were more sensitive to the convulsant action of strychnine and pentylenetetrazol and to electroshock. This increase in sensitivity to CNS stimulation was observed also in two other groups of rats which were given a diet with added sodium fluoride amounting to 7 and 70 parts per million in terms of fluoride. Prolonged treatment with fluoride also lengthened the sleeping time induced by pentobarbital and increased the protective effect of diphenylhydantoin against electroshock. The increase in sensitivity to some CNS-active agents in the fluoride-treated rats disappeared after these rats were given the control diet for 2 weeks,
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Fluoride Exposure and Neurodevelopmental Outcomes Among Children in the United States: A pilot study.
Background/Aim: Developmental neurotoxicity of fluoride has been demonstrated in animal studies. Additionally, fluoride exposure during prenatal development, infancy, middle-to-late childhood and adolescence has been associated with poorer neurodevelopmental outcomes among children in Mexico and/or Canada. However, potential impacts of chronic low-level fluoride exposure in early childhood on brain structure and
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Appetitive-based learning in rats: lack of effect of chronic exposure to fluoride.
BACKGROUND: Chronic ingestion of optimally fluoridated water (ca. 1.0 mg/L) has not been associated with any adverse health effects. Possible effects on the nervous system, however, have received little attention. One study with rats given high doses of fluoride reported subtle behavioral changes. The authors suggested that the ability of
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Aspects of nervous system affections in occupational fluorosis.
Neurological symptomatology in the form of the syndrome of vegetative-vascular dysfunction, or the asthenovegetative syndrome with polyneuritic (sensory and vegetative) disorders was detected in 78.8% of patients with occupational fluorosis in preosteal and osteal stages. Clinical and physiological investigations of the nervous system (psycho-physiological procedures, EEG, chronaximetry) showed patients with
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Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder.
The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized among the environmental risk factors of
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Effects of high fluoride on neonatal neurobehavioral development.
The effects of excessive fluoride intake during pregnancy on neonatal neurobehavioral development and the neurodevelopment toxicity of fluoride were evaluated. Ninety-one normal neonates delivered at the department of obstetrics and gynecology in five hospitals of Zhaozhou County, Heilongjiang Province, China were randomly selected from December 2002 to January 2003. The subjects were divided into two groups (high
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride & IQ: 67 Studies
As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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