Abstract
1. Round-the-clock exposure to hydrogen fluoride concentrations of 0.10 and 0.03 mg/m3 causes inhibition in the central nervous system, decreases the activity of a number of enzymes, impairs the phosphorus-calcium metabolism, and causes the accumulation of fluorine in the body and damage to the internal organs and bone tissue.
2. A hydrogen fluoride concentration of 0.01 mg/m3 should be regarded as the threshold concentration. Its effects on the body of the animals showed changes in the phosphorus metabolism only (inhibition of alkaline blood phosphatase and a delayed inclusion of radiophosphorus in bone tissue, liver, and blood at the end of a five-month exposure of the animals).
3. The mean daily maximum permissible concentration of hydrogen fluoride in the air of populated areas, adopted earlier as 0.01 mg/m3, should be lowered to 0.05 mg/m3.
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Studies on skeletal muscle biopsies in endemic skeletal fluorosis
Neurological manifestations of skeletal fluorosis have been attributed to compressive radiculomyelopathy. Experimental fluorosis has shown evidence of myopathic changes. Data on human muscle pathology is very scanty. This study included 22 patients with established osteofluorosis. 16 of them showed only EMG changes of neurogenic muscle disease. Histochemistry and histopathology of muscle biopsies showed
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Effects of fluorine on the human fetus.
In an endemic fluorosis area, 16 fetuses that were delivered during their sixth to eighth month of gestation by means of artificial abortion were collected and studied. The results [compared to 10 control fetuses from a non-endemic area] show that fluorine levels in tissues are obviously high, especially in brain, calvarium, and femur. The activity of alkaline
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Studies on sural nerve biopsies in endemic skeletal fluorosis
Sural nerve biopsies from 13 patients with radiologically confirmed skeletal fluorosis were studied for myelinated fibre densities, frequency distribution oftheir diameters, and single teased nerve fibre preparations. It was observed that most of the biopsies showed a marked reduction in myelinated fibre densities with more than half of them in:volving
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The pathogenesis of endemic fluorosis: Research progress in the last 5 years.
Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long-term direct
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Silymarin and quercetin abrogates fluoride induced oxidative stress and toxic effects in rats
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