Abstract
Inhibition on uptake of D-glucose by isolated intestinal epithelial cells (IIEC) was observed when the fluoride concentration ranged between 0.25 and 5 mM. Active transport was almost completely inhibited at 5 mM. When CaCl2 was added to fluoride, the inhibitory effect on glucose uptake was abolished. Preincubation of IIEC with different concentrations of fluoride (2.5-5.0 mM) for different intervals of time (2-20 min) at different pH levels (6.2-7.8) and temperatures (0-37 degrees C) revealed that the conditions which led to higher uptake of fluoride by IIEC produced maximum inhibition. The degree of inhibition was not appreciably altered by a change in glucose concentrations. A concentration-dependent effect of fluoride on lactic acid and carbon dioxide production by IIEC was also observed.
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Health problems in fluoride endemic areas of Gaya District
Fluoride (F) was estimated in the groundwater of six blocks (Bodh Gaya, Manpur, Wazirganj, Belaganj, Amas, and Bankebazar) of Gaya District, Bihar, for different physio-chemical properties e.g. pH, total dissolved solids(TDS), conductivity, turbidity, total hardness (TH), calcium, magnesium, iron and fluoride. Morever 93 blood samples from different age groups including
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Topical fluorides: effects on physiologic and biochemical processes
The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in
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Chronic fluoride exposure alters antioxidant enzymes in rat brain and intestine
Background: Low Fluoride use has been advocated as a therapeutic agent for delaying tooth decay however, high fluoride exposure has been associated with behavioral changes, low IQ, and altered brain functions and development. Although Fluoride generally does not generate free radicals but is still implicated in free radical associated damage
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Deleterious effect of sodium fluoride on gastrointestinal tract
1. The effect of sodium fluoride (NaF) on gastrointestinal tracts of rats was investigated. 2. Blood flow rate in rat stomach mucosa was only 30% of the initial rate during 30-60 min after a single oral dose (300 mg/kg) of NaF. 3. The addition of NaF (final NaF concentration: 50
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The effects of fluoride on the gastric mucosa of the rat
Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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