Abstract
Fluoride is a potent enzyme poison. Thirty ground water samples from Vellore District, Tamil Nadu, India were analysed for fluoride content and it was revealed that the fluoride content of 24 samples were over and above the permissible limits. In the present study, the experimental rats were orally treated with 25 ppm of fluoride/rat/day for 8 and 16 weeks, respectively, and the levels of lipid peroxidation and antioxidant enzymes were studied to evaluate fluoride intoxication. An increase in the level of lipid peroxides along with a concomitant decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione content were observed in fluoride administered groups of rats. The altered antioxidant status may be attributed to the increased generation of free radicals.
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Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1?/Sirt3.
Highlights Honokiol attenuated fluoride-induced cognitive deficits in mice. Honokiol prevented neuronal/synaptic injury in the hippocampus of fluoride-treated mice. Honokiol inhibited oxidative stress and mitochondrial abnormalities following fluoride challenge. The AMPK-PGC-1?-Sirt3 pathway was involved in the honokiol’s positive effects on fluoride-induced mitochondrial dysfunction. Oxidative stress and mitochondrial dysfunction contribute greatly to
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Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity in Drosophila melanogaster.
Sodium fluoride (NaF) is used in water fluoridation and dental products such as mouth rinses and toothpastes. Resveratrol is a natural polyphenol with antioxidant and anti-inflammatory properties. The present study was carried out to evaluate the toxicity of NaF and the protective role of resveratrol in Drosophila melanogaster. For longevity
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Induction of apoptosis in human gingival epithelial cells by sodium fluoride.
Fluoride (F) causes not only chronic but also short-term toxic effects, such as apoptosis, in several kinds of human cells. Although human gingival epithelial cells (HGECs) are frequently exposed to topical applications of F to teeth, the apoptosis effects of F on HGECs does not appear to have been assessed.
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Fluoride-induced oxidative stress is involved in the morphological damage and dysfunction of liver in female mice
Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely unknown. In this study, the morphological and ultrastructural characteristics of liver were observed using hematoxylin and eosin staining and transmission electron
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Implication of glutiathione in endemic fluorosis
In a new approach to an understanding of the genesis of nonskeletal and skeletal fluorosis, glutathione content in blood was investigated. Thirty cases of fluorosis and forty controls (20 from fluorotic and 20 from nonfluorotic areas) were studied. In fluorotic subjects, blood glutathione concentration was significantly elevated. Urinary hydroxyproline and
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
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Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
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