Excerpt:

The familial pituitary or central diabetes insipidus (DI) is a relatively rare condition with variable onset, from birth to several years of age and variable severity within a family and in individuals over time(l). Severe dehydration and growth retardation, though rare are known compilations of DI. However, dental fluorosis as a complication of DI has been described in the literature only in three families(2,3). Further, severe crippling deformities due to skeletal fluorosis has not been reported in the literature to the best of our knowledge. We report two brothers with central diabetes insipidus who developed severe skeletal and dental fluorosis from early childhood.

Print PDF

• Related Studies :

  • Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.

    Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary

  • The pathogenesis of endemic fluorosis: Research progress in the last 5 years.

    Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long-term direct

  • Subacute fluorosis

    A young woman presented with a novel multisystem disease: painful periostitis, osteosclerosis, hypertension, and renal dysfunction. The similarity of some of this clinical picture to fluoride intoxication led to the discovery of massively elevated fluoride levels in serum, urine, and bone. Although initially an enigma, the source of fluoride was

  • Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology. [Article in Japanese]

    The authors' research focuses on polyuria, natriuresis, glucosuria, glycemia, and renal calcification in occupational lead poisoning and endemic fluorosis. Changes in electrolyte mobilization and in glucose metabolism and transport following the administration of lead compounds or fluoride were examined to elucidate these mechanisms. The results suggest fundamental approaches to the

  • Skeletal radiographic appearances of high aluminum fluorosis caused by domestic coal fuel (analysis of 39 cases)

    PURPOSE: To find out the skeletal radiologic appearances of high aluminum fluorosis caused by burning coal as domestic fuel. MATERIALS AND METHODS: Thirty-nine cases of high aluminum fluorosis caused by eating corns baked by coal and china clay were studied. The authors also investigated the environmental conditions, clinical appearances and other laboratory test

• Related FAN Content :

  • Skeletal Fluorosis in the U.S.

    Although there has been a notable absence of systematic studies on skeletal fluorosis in the U.S., the available evidence indicates that the consumption of artificially fluoridated water is likely to cause skeletal fluorosis and other forms of bone disease in people with kidney disease and other vulnerable populations.

  • Skeletal Fluorosis: The Misdiagnosis Problem

    It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

  • Fluoride & DISH (Diffuse Idiopathic Skeletal Hyperostosis)

    Among individuals with skeletal fluorosis, the fluoride-induced changes to the spine, and the accompanying symptoms, can bear a close resemblance to DISH (Forestier's Disease). Some authors report that skeletal fluorosis can so closely resemble that DISH that the only way to distinguish the two would be to conduct an invasive bone biopsy. No studies have ever been conducted to determine what role, if any, fluoride plays in the development of DISH.

  • NRC (2006): Fluoride's Effect on Glucose Metabolism

     This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific

  • Estimated "Threshold" Doses for Skeletal Fluorosis

    For over 40 years health authorities stated that in order to develop crippling skeletal fluorosis, one would need to ingest between 20 and 80 mg of fluoride per day for at least 10 or 20 years. This belief, however, which played an instrumental role in shaping current fluoride policies, is now acknowledged by the National Academy of Sciences (NAS) and other US health authorities to be incorrect.