Abstract
Female mice were fed a low fluoride diet (0.1 to 0.3 ppm fluoride) plus drinking water containing 0, 50, 100 or 200 ppm fluoride as sodium fluoride. Toxic effects of fluoride were evidenced by retarded growth and impaired reproduction in mice with intakes of 100 and 200 ppm fluoride, and the higher level resulted in a high mortality rate (50% deaths in 5 weeks). Mice with a low fluoride intake developed signs of fluorine deficiency, with a progressive development of infertility in two successive generations. Growth rate and litter size were not affected by the low fluoride intake, but the percentage of mice producing litters was lower, and the age at delivery of the first litter was greater than in mice receiving 50 ppm fluoride.
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Natrium fluoride influences methylation modifications and induces apoptosis in mouse early embryos
Fluoride is considered a major pollutant of ground water and can cause cytotoxicity in a concentration-dependent manner. This study epigenetically examined the effect of fluoride on early embryos of Kunming mice administered with 0, 20, 60, and 120 mg/L sodium fluoride (NaF) for 30 days. The results showed that NaF
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Reproductive toxic effects of ingestion of sodium fluoride in female rats
The objective of this study was to investigate the toxic effects of different concentrations of sodium fluoride (200, 400 and 600 ppm NaF), administered in drinking water for 30 days, on the reproductive system of adult female Sprague-Dawley rats. The rats in the two higher-dosed groups showed clinical signs of
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The influence of fluorides on mouse sperm capacitation
Increasing infertility, due to pathological changes on sperm, has become a serious issue. Eco-toxicological effect of rising concentration of fluorides can be enhanced in the presence of aluminium ions by forming fluorometallic complexes, analogues of phosphate groups that interfere with the activity of G-proteins and P-type ATPases, which are part
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Exposure to high fluoride concentrations in drinking water is associated with decreased birth rates
A review of fluoride toxicity showed decreased fertility in most animal species studied. The current study was to see whether fluoride would also affect human birth rates. A U.S. database of drinking water systems was used to identify index counties with water systems reporting fluoride levels of at least 3
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Fluoride impairs oocyte maturation and subsequent embryonic development in mice
The damage caused by fluorosis is permanent, and has been recognized as a public health problem in a number of regions of the world. Although multiple studies provided evidence that sodium fluoride (NaF) elicits adverse effects on reproductive function, the effect of fluoride on female germ cell development is not
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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