Abstract
Albino rabbits were injected sodium fluoride solutions in the concentration of 5, 10, 20 and 50 mg/kg body weight/day subcutaneously for 100 days. The control rabbits were given 1 cc of distilled water for the same period and sacrificed. The ovary was examined for histopathological changes. Animals in control and 5 mg fluoride treated groups displayed normal follicles with oocytes and interstitial tissue in ovaries. In animals treated with 10 and 20 mg fluoride, ovary exhibited congested oocytes in the follicles, necrosis of follicle cells and interstitial oedema. The degenerative changes were most pronounced in animals treated with 50 mg fluoride, in which complete atrophy of follicles along with oocyte disintegration and marked necrosis of cells accompanied by infiltration of monocytes, lymphocytes and histiocytes in interstitial tissue occurred. The data indicate that the structural alterations in the ovary were more pronounced with the concomitant increase in the dose of fluoride.
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The influence of excess fluorine intake in the drinking water on reproductive efficiency in bovines
Observations were made over four breeding seasons to determine the effect of excessive intake of fluorine in the drinking water on the breeding efficiency of cattle. Fifty Afrikaner heifers, maintained under ordinary ranching conditions, were divided into five groups which received 5, 8 and 12 ppm fluorine respectively in the drinking
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A Rat Experimental Study of the Relationship Between Fluoride Exposure and Sensitive Biomarkers.
Chronic excessive fluoride exposure impairs human health and damages not only the skeletal system and the teeth but also the soft tissues such as the brain, liver, kidneys, pancreas and spinal cord. However, there is limited research regarding the exposure levels and sensitive biomarkers. This study was aimed to establish
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Fluoride Impairs Ovary Development by Affecting Oogenesis and Inducing Oxidative Stress and Apoptosis in Female Zebrafish (Danio Rerio).
Highlights Fluoride exposure decreased FSH, LH and VTG levels in ovary of zebrafish. Fluoride exposure altered the transcriptional profiles of oogenesis-related genes. Fluoride exposure increased ROS production in ovary of zebrafish. Fluoride exposure induces oxidative stress in ovary of zebrafish. Fluoride exposure induces apoptosis through both extrinsic and intrinsic
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Excess dietary fluoride affects laying performance, egg quality, tissue retention, serum biochemical indices, and reproductive hormones of laying hens.
The present study aimed to evaluate the effects of excess dietary fluoride (F) on laying performance, egg quality, tissue retention, serum biochemical indices, and serum reproductive hormones of laying hens. A total of 384 Hy-Line Gray hens, 37 wk old, were treated with sodium fluoride added to a corn-soybean meal
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The MMP-9/TIMP-1 System is Involved in Fluoride-Induced Reproductive Dysfunctions in Female Mice.
A total of 84 healthy female mice were kept with various concentrations of sodium fluoride (F) (0, 50, 100, 150 mg F-/L in drinking water for 90 days) and were then mated with healthy male mice for 1 week to study the effect of excessive fluoride on female reproductive function, particularly in embryo
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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