Abstract
The aim of the study was to evaluate relationship between infertility and the histological structure of the testes following the subcutaneous administration of different doses of sodium fluoride (5, 10, 20 and 50 mg/kg/day), for 100 days, to groups of six male albino rabbits; the six control animals were given 1 cc distilled water/kg b.w./day for the same length of time. Deficient maturation and differentiation of the spermatocytes and an increase in the amount of interstitial tissue were found in the experimental animals. In the higher dosage groups, spermatogenesis stopped and the seminiferous tubules became necrotic. The study thus established the existence of a definite relationship between fluorosis and testicular damage.
-
-
Effects of sodium fluoride on the reproductive development of Bombyx mori.
Highlights Studies on the reproductive toxicity of fluoride to invertebrates using lepidopteran model insects, Bombyx mori. We demonstrated reproductive toxicity of fluoride toward Bombyx mori at physiological, biochemical and pathology levels. The results provide a theoretical basis for revealing the reproductive toxicity of fluoride in terrestrial insects. Bombyx mori was used
-
Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice
Fluoride and sulfur dioxide (SO2), two well-known environmental toxicants, have been implicated to have adverse effects on male reproductive health in humans and animals. The objective of this study to investigate if the BTB is one of the pathways that lead to reproductive toxicity of sodium fluoride and sulfur dioxide
-
Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies.
Highlights Fluoride induces severe mitochondrial damage in Leydig cells, as well as in germ and Sertoli cells. Fluoride induces mitophagy in testicular tissues, especially in Leydig cells. Fluoride decreases the mitochondrial membrane potential and increases the number of lysosomes in Leydig cells. PINK1/Parkin pathway maybe plays an important role in
-
Effects of protein supplementation and deficiency on fluoride-induced toxicity in reproductive organs of male mice
Feeding a protein-deficient diet to male mice treated for 30 days with NaF (5, 10, 20 mg/kg body weight) caused a significant decrease in protein levels in testeis, cauda epididymis, and vas deferens. The activity of testicular SDH and 3B- and 17B-HDS as well as ATPase in cauda epididymis and
-
Fluoride exposure alters the ultra-structure of sperm flagellum via reducing key protein expressions in testis.
Highlights Fluoride damaged the typical “9 + 2" microtubule structure of sperm flagellum. Fluoride reduced AKAP3 and AKAP4 expressions related to fibrous sheathes formation. CFAP43, CFAP44 and HYDIN expressions in sperm axoneme were down-regulated by fluoride. Fluoride did not affect Dnah1, Eno4, Spef2, Spag6, Spag16, and Cfap69 expressions in testes. Excessive
Related Studies :
-
-
-
Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
-
Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
-
Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
-
Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
Related FAN Content :
-