Abstract
The aim of the study was to evaluate relationship between infertility and the histological structure of the testes following the subcutaneous administration of different doses of sodium fluoride (5, 10, 20 and 50 mg/kg/day), for 100 days, to groups of six male albino rabbits; the six control animals were given 1 cc distilled water/kg b.w./day for the same length of time. Deficient maturation and differentiation of the spermatocytes and an increase in the amount of interstitial tissue were found in the experimental animals. In the higher dosage groups, spermatogenesis stopped and the seminiferous tubules became necrotic. The study thus established the existence of a definite relationship between fluorosis and testicular damage.
-
-
Effects of high fluoride on sperm quality and testicular histology in male rats
Sixty-four forty-day old male Wistar rats were divided randomly into two groups of thirty-two each. With one group untreated as controls, the other group was administered 150 mg NaF/L (68 ppm F–) in their drinking water to assess the effects of high fluoride on sperm quality and testicular histology at
-
A study of the effect of high concentrations of fluoride on the reproductive organs of male rabbits, using light and scanning electron microscopy
Fluoride was orally administered to rabbits at 10 mg NaF/kg body weight for 18 or 29 months. The animals were then killed and the structure of the testis, epididymis and vas deferens studied under light and scanning electron microscopes. In animals treated for 29 months, the spermatogenic cells in the
-
[Effect of endemic fluoride poisoning caused by coal burning on the oxidative stress in rat testis].
OBJECTIVE: To explore the effect of endemic fluoride poisoning caused by coal burning on the oxidative stress in rat testis. METHODS: Totally 40 male SD rats were equally randomized into four groups control group, low fluorosis group, middle fluorosis group, and high fluorosis group. Rats in all three fluorosis groups were
-
Histological finding of mice testes following fluoride ingestion
The study was designed in order to assess the relationship between infertility and histological structure of testes following administration of varying doses of sodium fluoride. One hundred adult male albino mice were fed 10 ppm (Group A), 500 ppm (Group B) and 1000 ppm (Group C) of sodium fluoride in
-
Fluoride-induced unrestored arrest during haploid period of spermatogenesis via the regulation of DDX25 in rats.
Highlights Fluoride-induced unrestored arrest during haploid period of spermatogenesis. Fluoride down-regulated of DDX25 and associated regulatory protein CRM1, HMG2, H4, TP2, and PGK2 in testes. Fluoride exposure altered the structure of chromatoid bodys and reduced its molecular components in the testes. The reversibility of fluoride toxicity is dose-dependent on male
Related Studies :
-
-
-
Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
-
Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
-
Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
-
Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
Related FAN Content :
-