Abstract

Fluoride in drinking water decreased the total quantity of enamel matrix protein formed in rat incisors and altered the relative proportions of individual amino acids of the matrix.

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    Dental fluorosis is caused by chronic high-level fluoride (F-) exposure during enamel development, and fluorosed enamel has a higher than normal protein content. Matrix metalloproteinase 20 cleaves enamel matrix proteins during the secretory stage, and KLK4 further cleaves these proteins during the maturation stage so that the proteins can be

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