Abstract

OBJECTIVE:  To study the endocrine disturbing effect of fluorin on Hypothalamus-Hypophysis-Testis axis in male rats.

METHODS:  A total of 36 Wister male rats weighting 60-70 g were randomly divided into group I (high fluoride group of F-100 mg/l), group II (low fluoride group of F- 30 mg/l), group III (control group with pure water), with 12 rats in each group. Fluoride was administered with drinking water for 8 weeks. Then the level of procreation hormone in serum was detected by RIA method. And the spermatozoa quality was analysized.

RESULTS:  There was difference between group I, group II and group III each other (P < 0.05) in body weight. As to right testis weight, there was difference between group I, group II and group III each other (P < 0.05). Epididymide organic coefficient in group II and group I were lower than that in group III (P > 0.05). Compared with group III, the counts amount of sperm and the rates of sperm mobility in group II and group I singnificantly increased (P < 0.05), and the rates of sperm aberration in group II and group I significantly decreased (P < 0.05), compared with group II, the sperm quality of group I descreased significantly (P < 0.05). The level of GnRH in three groups were significant difference between each groups (P <0.05). The level of FSH in three groups were significant difference between each groups (P < 0.05). The level of ICSH in three groups were no significant difference between each groups (P > 0.05). The level of T in Group I is significant lower than that of in Group II and Group III (P < 0.05). The level of E2 in Group I is significant higher than that of in Group II and Group III (P < 0.05).

CONCLUSION:  These data support our hypothesis that fluorin have no significant effect on the function of male Rat Hypothalamus, that fluorin may effect the function of male Rat Hypophysis, that T/ICSH can be used to find the functional change of Leydig cells. Fluorin could affect hormone levels of each layer of the Hypothalamus-Hypophysis-Testis axis, and show the male reproductive endocrine disturbing effects.

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