Abstract

Dr. Richard Daley, Dr. Lewis D. Anderson, and Dr. Richard S. Riggins discussed the effects of high fluoride diets on bone tissue. Severe restrictions of calcium intake in growing rats produces a histological picture resembling osteoporosis. In this study a control series of rats, fed adequate amounts of calcium, was compared with three test groups receiving a low-calcium diet; a low-calcium, low-fluoride diet; and a low-calcium, high-fluoride diet, respectively. In the rats fed a low-calcium, low-fluoride diet the bone was not significantly different from that of the rats of the low-calcium diet. The bone from both of these groups fractured under smaller loads than did normal bone. There was no significant difference in the loads supported by the bone from any of the three low-calcium groups; however, the heavily fluorinated bone tended to break under less stress than did bone from any other group. These findings suggest that the heavily fluorinated bone was not as strong as the bone from normal rats or from rats fed low-calcium diets without fluoride.

• Related Studies :

  • Fluoride content and mineralization of red deer (Cervus elaphus) antlers and pedicles from fluoride polluted and uncontaminated regions

    Fluoride, calcium, and phosphorus content as well as ash percentage and ash density of primary antlers and pedicle bones were studied in nine yearling red deer stags from a fluoride polluted region in North Bohemia (Czech Republic) and in nine control animals from two uncontaminated areas in West Germany. Fluoride

  • Compressive properties of cortical bone: mineral-organic interfacial bonding

    Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties, orientation and interfacial bonding interactions. Interfacial bonding between the mineral and

  • On fluoride and bone strength

    The recent paper by Einhorn et al. [1] drew the conclusion that fluoride incorporation into bone does not impair bone's mechanical properties. This result is in conflict with the results of others concerning fluoride and bone strength. For instance, several investigators--including ourselves--have shown that bone strength decreases as bone fluoride

  • Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats

    Ingested fluoride is incorporated into bone apatite and can affect the structural integrity of bone. Fluoride absorption in the gut and incorporation into bone is affected by the presence of other ions, including calcium. We hypothesized that a low calcium phosphate diet combined with high fluoride intake would have independent

  • Effect of fluoride on bone formation and strength in Japanese quail

    The effect of fluoride on bone metabolism was studied using Japanese quail fed diets containing 1.2% calcium, 1.2% calcium + 0.075% fluoride, 0.4% calcium, and 0.4% calcium + 0.075% fluoride. In the first experiments, quail were fed the diets immediately after hatching. Low calcium intake (0.4%) resulted in a 23%

• Related FAN Content :

  • "Pre-Skeletal" Fluorosis

    As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.

  • The Relationship Between Fluoride, Bone Density, and Bone Strength

    Although fluoride has generally been found to reduce the bone density of cortical bone, it is well documented that fluoride can increase the density of trabecular bone (aka cancellous bone). Trabecular  bone is the primary bone of the spine, whereas cortical bone is the primary bone of the legs and arms. While increases in

  • Mechanisms by which fluoride may reduce bone strength

    Based on a large body of animal and human research, it is now known that fluoride ingestion can reduce bone strength and increase the rate of fracture. There are several plausible mechanisms by which fluoride can reduce bone strength. As discussed below, these mechanisms include: Reduction in Cortical Bone Density De-bonding of

  • Skeletal Fluorosis: The Misdiagnosis Problem

    It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

  • In Vitro Studies on Fluoride & Bone Strength

    The "in vitro" research on fluoride and bone strength confirms what has repeatedly been found in animal and human studies: the more fluoride a bone has, the weaker the bone becomes. In an in vitro bone study, the researcher directly exposes a human or animal bone to a fluoride solution