Abstract
The therapeutic use of sodium fluoride has been recommended in a variety of osteopenic bone diseases. The recommendations are based mainly on the known osteosclerotic effects of sodium fluoride and little information is available as to its effect on bone strength. The influence of various concentrations of sodium fluoride on bone strength in growing rats on high nnd low calcium diets was studied. The administration of sodium fluoride increased bone diameter, indicating stimulation of periosteal hone formation, but bone strength was reduced or not affected by fluoride ingestion.
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Effect of fluoride on bone formation and strength in Japanese quail
The effect of fluoride on bone metabolism was studied using Japanese quail fed diets containing 1.2% calcium, 1.2% calcium + 0.075% fluoride, 0.4% calcium, and 0.4% calcium + 0.075% fluoride. In the first experiments, quail were fed the diets immediately after hatching. Low calcium intake (0.4%) resulted in a 23%
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On fluoride and bone strength
We welcome the opportunity to respond to the letter by Baylink et al. Their letter makes many good points but, unfortunately, it also contains several misinterpretations of our analysis. The thesis of Baylink's letter and the paper of Einhorn et al. [1] is that fluoride incorporation into cortical bone does
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The effect of fluoride supplementation on the strength of osteopenic bone
The strength of osteopenic bone from calcium deprived rats, quail and roosters was significantly reduced after fluoride supplementation. Using a device which measures torque, femurs from rats fed low calcium diets with 100 parts per million fluoride added to the water supply fractured at lower torque values than those values
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Fluoride and nutritional osteoporosis: Physicochemical data on bones from an experimental study in dogs
Osteoporosis was induced by feeding a low calcium-high phosphorus diet for 41 weeks to adult beagles. The effect of fluoride to modify this condition was examined by adding increasing levels to the purified diet; daily intake of fluoride was about 0, 25, 85, 300 and 1,000 /ug/kg body weight. Radiographic
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Effects of estrogen on bone composition in rats at low and high fluoride intake
Bone examinations were carried out on female rats which had received estradiol benzoate and drinking water containing either 0.55 or 50 ppm of fluoride (F). The estradiol benzoate was injected subcutaneously twice weekly and the rats were killed after 2, 4 and 6 weeks. The results showed that estrogen treatment
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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