Abstract
The therapeutic use of sodium fluoride has been recommended in a variety of osteopenic bone diseases. The recommendations are based mainly on the known osteosclerotic effects of sodium fluoride and little information is available as to its effect on bone strength. The influence of various concentrations of sodium fluoride on bone strength in growing rats on high nnd low calcium diets was studied. The administration of sodium fluoride increased bone diameter, indicating stimulation of periosteal hone formation, but bone strength was reduced or not affected by fluoride ingestion.
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Effect of fluoride on bone formation and strength in Japanese quail
The effect of fluoride on bone metabolism was studied using Japanese quail fed diets containing 1.2% calcium, 1.2% calcium + 0.075% fluoride, 0.4% calcium, and 0.4% calcium + 0.075% fluoride. In the first experiments, quail were fed the diets immediately after hatching. Low calcium intake (0.4%) resulted in a 23%
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Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats
Ingested fluoride is incorporated into bone apatite and can affect the structural integrity of bone. Fluoride absorption in the gut and incorporation into bone is affected by the presence of other ions, including calcium. We hypothesized that a low calcium phosphate diet combined with high fluoride intake would have independent
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On fluoride and bone strength
We welcome the opportunity to respond to the letter by Baylink et al. Their letter makes many good points but, unfortunately, it also contains several misinterpretations of our analysis. The thesis of Baylink's letter and the paper of Einhorn et al. [1] is that fluoride incorporation into cortical bone does
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High fluoride and low calcium levels in drinking water is associated with low bone mass, reduced bone quality and fragility fractures in sheep
Chronic environmental fluoride exposure under calcium stress causes fragility fractures due to osteoporosis and bone quality deterioration, at least in sheep. Proof of skeletal fluorosis, presenting without increased bone density, calls for a review of fracture incidence in areas with fluoridated groundwater, including an analysis of patients with low bone
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Fluoride and nutritional osteoporosis: Physicochemical data on bones from an experimental study in dogs
Osteoporosis was induced by feeding a low calcium-high phosphorus diet for 41 weeks to adult beagles. The effect of fluoride to modify this condition was examined by adding increasing levels to the purified diet; daily intake of fluoride was about 0, 25, 85, 300 and 1,000 /ug/kg body weight. Radiographic
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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In Vitro Studies on Fluoride & Bone Strength
The "in vitro" research on fluoride and bone strength confirms what has repeatedly been found in animal and human studies: the more fluoride a bone has, the weaker the bone becomes. In an in vitro bone study, the researcher directly exposes a human or animal bone to a fluoride solution
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Fluoride & Rickets
One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid (unmineralized bone) content of bone. When bones have too much osteoid, they become soft and prone to fracture -- a condition known as osteomalacia. When osteomalacia develops during childhood, it is called "rickets." The potential for fluoride
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Factors which increase the risk for skeletal fluorosis
The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.
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