The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice.

The objective of the present study was to explore the molecular mechanism of apoptosis induced by sodium fluoride (NaF) in the mouse kidney by using the methods of flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and experimental pathology. 240 four-week-old ICR mice were randomly divided into 4

Histological and histochemical appearance of livers and kidneys of rats after long-term treatment with different concentrations of sodium fluoride in drinking water

After a review of the controversies in the literature, a histologic and histochemical study of the livers and kidneys of 48 albino rats was performed. The animals were placed on a diet containing 1 ppm NaF in demineralized drinking water, or 1, 10 or 100 ppm NaF in tap water

Evaluation of serum lipoprotein and tissue antioxidant levels in sheep with fluorosis

The aim of this study was to evaluate serum lipoprotein and tissue antioxidant levels of sheep with and without fluorosis living in a volcanic area of Turkey. Fifteen Akkaraman sheep with fluorosis in the A?ri region north of Lake Van and 10 Akkaraman sheep without fluorosis in the Van region

Changes of acute harmful effects and fluoride kinetics after single intravenous injection of sub-toxic hydrofluoric acid in rats-Renal dysfunction, abnormal serum electrolytes, metabolic acidosis and fluoride kinetics.

Hydrofluoric acid (HFA) is used widely in many industrial processes. There have been many reports on the acute lethal effects of HFA in relation to occupational accidents. This study was designed to investigate the time-dependent harmful effects after exposure of sub-toxic doses. The serum fluoride ion (F) kinetics is also

Chronic toxicity of dietary sodium monofluorophosphate in growing rats, with special reference to kidney changes

Fluoride as a Cause of Kidney Disease in Humans

Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing

Fluoride Gels & Kidney Function

Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each

Kidney: A potential target for fluoride toxicity

The kidneys are the organ responsible for clearing fluoride from the body. In the process of doing so, the kidneys are exposed to concentrations of fluoride that exceed, by a factor of 50, the concentration of fluoride in human blood. As such, the kidney have long been considered a potential

Fluoride & Kidney Stones

It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium

Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence

A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.