The fluoride sensitivity of cells released from rat livers and kidneys by collagenase perfusion was investigated by measuring effect on protein synthesis rate in vitro. Both cell types were sensitive to fluoride with clear concentration/effect relationships. Significant difference in sensitivity for fluoride between the cell types was found, with the kidney cells being the most sensitive type.
Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity
This study describes alterations in the nervous system resulting from chronic administration of the fluoroaluminum complex (AlF3) or equivalent levels of fluoride (F) in the form of sodium-fluoride (NaF). Twenty seven adult male Long-Evans rats were administered one of three treatments for 52 weeks: the control group was administered double
Sodium fluoride induced histopathalogical changes in liver and kidney of albino mice.
Fluoride is a well determined non-biodegradable and moderate pollutant, which at high levels causes serious health problems. The present study was designed to investigate the histopathalogical changes in liver and kidney of exposure to sodium fluoride in albino mice. Eighteen adult albino mice were divided into 3 groups (6 mice
Acute fluoride toxicity: The influence of acid-base status.
The influence of preexisting acid-base disturbances on acute fluoride toxicity was studied in anesthetized rats. Metabolic acidosis was induced by the administration of NH4Cl and alkalosis by NaHCO3. Fluoride was infused i.v. until death occurred. One experiment involved intact animals (n = 18); another study used nephrectomized animals (n =
Differential expression of osteopontin and bax, bcl-2 by fluoride.
OBJECTIVE: To study the differential expression of bax, bcl-2 and osteopontin by fluoride in the renal tubular cells in vitro. METHODS: The renal tubular cells were cultured and exposed to sodium fluoride (NaF) in 1, 5, 7.5, 12.5 mg F-/L level. The transcription level of bax, bcl-2 and osteopontin were investigated
The role of calcium in ameliorating the oxidative stress of fluoride in rats
The present study was carried out to investigate the effects of fluoride toxicity on some biochemical, hormonal, and histological parameters of female rats and the protective role of calcium against such effects. Adult female albino rats were divided into five groups; control group received distilled water for 60 days, calcium
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