The fluoride sensitivity of cells released from rat livers and kidneys by collagenase perfusion was investigated by measuring effect on protein synthesis rate in vitro. Both cell types were sensitive to fluoride with clear concentration/effect relationships. Significant difference in sensitivity for fluoride between the cell types was found, with the kidney cells being the most sensitive type.
Radiofluoride distribution in tissues of normal and nephrectomized rats.
Summary 1) Radiofluoride given by intraperitoneal injection was absorbed and distributed throughout fluid compartments of the rat. It was found in concentrations exceeding that of plasma in the skeleton and in the tail tendon. In all other soft tissues examined, concentration in tissue water was some fraction of plasma concentration. Tissue
Toxic effects of fluoride on kidney function and histological structure in young pigs
The effects of chronic fluoride exposure on kidney integrity and histological structure, along with effects on associated enzymes and metabolite changes, were investigated in young pigs. Twenty-four crossbred barrows (Duroc×Landrace×Yorkshire) about 50 days old were randomly divided into three groups of eight pigs each. Groups I, II, and III received
Alterations in drug metabolising enzymes and lipid peroxidation in different rat tissues by fluoride.
Sodium fluoride at a dose level of 5.0 mg/kg enhanced aminopyrine N-demethylase and NADPH cytochrome c reductase activities and cytochrome P450 and cytochrome b5 levels in rat liver, kidney, lung, intestine and testis, whereas acetanilide hydroxylase activity remained unchanged in kidney and lung and was increased in liver, intestine and
[Study on the relationship between renal apoptosis and expression of caspase protein in fluoride induced rat].
OBJECTIVE: To study the relationship between death receptor pathway, mitochondrion pathway and fluoride-induced apoptosis of renal cell. METHODS: Male Sprague-Dawley rats were divided randomly into four groups (control, low-fluoride, medium-fluoride,and high-fluoride) and administered 0, 50, 100, and 200 mg/L of sodium fluoride, respectively, via drinking water for 120 days. The incidence
Effect of chronic exposure to sodium fluoride and 7,12- dimethylbenz[a]anthracene on some blood parameters and hepatic, renal, and cardiac histopathology in rats.
This study aimed to investigate the effects of both sodium fluoride (NaF) and 7,12-dimethylbenz[a]anthracene (DMBA), both separately and in combination, on some blood parameters and hepatic, renal, and cardiac histopathology in rats. Forty male Wistar albino rats, weighing 250–300 g, were randomly divided into one control and three experimental groups
Related Studies :