The oestrone loading test was carried out on fifteen patients suffering from fluorine liver damage. Three pattern curves of the oestrogen fraction (oestrone, 17?-oestradiol and oestriol) excretion in the urine were established. Our data show that there were disturbances in oestrogen metabolism in patients with fluorine liver damage.
Lead enhances fluoride influence on apoptotic processes in the HepG2 liver cell line.
Chronic long-term exposure to high levels of fluoride leads to fluorosis, manifested by skeletal fluorosis and damage to internal organs, including kidneys, liver, parathyroid glands, and brain. Excess fluoride can also cause DNA damage, trigger apoptosis, and change cell cycle. The effect of fluoride may be exacerbated by lead (Pb),
Amelioration of the Protein Expression of Cox2, NFkB, and STAT-3 by Some Antioxidants in the Liver of Sodium Fluoride-Intoxicated Rats.
The present study aimed to explore the efficiency of N-acetyl cysteine (NACC) or thymoquinone (TMQ) alone or in combination in the downregulation of inflammatory molecule expression and decreasing hepatic injury in response to sodium fluoride (SF). Sodium fluoride upregulated serum alanine and aspartate transferases activities, tumor necrosis factor ? and
N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes
Fluoride induces the overproduction of free radicals, which might in turn affect various biochemical parameters. Therefore, the aim of this study was to elucidate the role of N-acetylcysteine (NAC) in decreasing fluoride-induced oxidative stress. The fluoride intoxicated (0.002; 0.082; 0.164mmol/l) rat hepatocytes was pre-treated (60min) and simultaneously treated with NAC
Histologic findings in the kidney, liver, pancreas, adrenal, and thyroid glands of the rat following sodium fluoride administration
1. Fluoride toxicosis was induced in young rats of the Long-Evans strain. Ten rats received a total of 406.47 mg. each of sodium fluoride injected intraperitoneally over a fifteen-day period, to induce acute poisoning. Seven rats survived, of which six were analyzed for this study. Ten others received a total
Induction of oxidative stress and related transcriptional effects of sodium fluoride in female zebrafish liver
The effects of sodium fluoride (NaF) exposure on the induction of oxidative stress and alteration of gene expressions were studied in the liver of female zebrafish (Danio rerio). Zebrafish, exposed to 15 ppm NaF for 30 and 90 days, exhibited liver histopathology including hyperplassia, cytoplasmic degeneration and nuclear fragmentation. Antioxidant enzyme (GST,
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