In this paper, we analyzed the quantification of serum lipoprotein performed on 30 cases (the mean age being 41 years old) with fluorine-associated aortic sclerosis, and 31 healthy adults (the mean age being 40.5 years old) were included in the control group. The determination of T-ch, HDL, LDL, VLDL and HDL/T-ch was performed on [all cases] in these two groups; the significance of differences was verified with the t test, and correlation analysis was made. Results demonstrated that HDL and HDL/T-ch for the fluorosis group were significantly lower than those for the control group, and VLDL for the fluorosis group was higher than that for the control group, but all those values did not exceed the normal ranges. VLDL, LDL and T-ch were positively correlated to the thickness of aortic wall measured by two-dimensional echocardiography, r being 0.45, 0.54 and 0.55 respectively. The relation between the pathogenesis of fluorine-associated aortic sclerosis and serum lipids was discussed, and the conclusion was as follows: The increased incoming Ca++ may cause the functional failure of muscle cells and their subsequent necrosis, resulting in local calcification and ulceration; in addition, the pathogenesis of fluorine-associated aortic sclerosis may be related to the important synergic action of fluorine ions with the enzyme system in the human body; the excessive uptake of fluorine may cause dysfunction of the enzyme system in the human body, leading to the elevation of VLDL and the reduction of HDL in the blood, and subsequent pathological changes of vascular walls.