Abstract
Fluorosis is an important public health problem in certain parts of India. Chandrapur is one of the fluorosis endemic district of Maharashtra. An investigation was undertaken in three villages of study area to assess the clinical symptoms of skeletal fluorosis and in turn to find out the severity of the disease. A door to door approach with face to face interviews of the study population was carried out and classified into three age groups i.e. 30-45 yrs (529), 46-60 yrs (387) and 61 yrs to above (262) for different grades of clinical symptoms and collected information was entered in a precoded questionnaire. Fluorosis was diagnosed clinically and as well as the drinking water samples were tested for fluoride level. The concentration of fluoride in drinking water varies from 0.66 to 5 mg/l. Among the 1178 subjects (572 males and 606 females) surveyed 367 (31.15%) patients exhibited the symptoms of different grades of skeletal fluorosis. The skeletal symptoms including tingling and numbing of extremities, joint pain in both upper and lower limbs, unable to bend, unable to bend neck, back pain, shoulder pain and knock-knee. Prevalence of skeletal fluorosis was found to be 20.22% (30-45 yrs), 34.62% (46-60 yrs) and 48.09% (61 yrs to above). A direct association existed between age and severity of skeletal fluorosis. A higher prevalence was recorded in the older one (61 yrs to above). With advancing age, the prevalence of skeletal fluorosis increased and it was more prevalent among males (36.18%) than the females (26.40%).
-
-
Bone mineral structure after six years fluoride treatment investigated by backscattered electron imaging (BSEI) and small angle x-ray scattering (SAXS): a case report
NaF, a bone formation stimulating agent, is used for the treatment of osteoporosis. Controversy exists concerning the quality of the newly formed bone and the antifracture effectiveness. We report about a 70 years old woman, who had received 50 mg NaF/d for about 6 years. Calcium or Vit D supplements
-
The impact of fluoride in drinking water on oral health and skeletal system of school children
Modern life styles even among people in rural areas have created an increased demand for dental cosmetology. Dental fluorosis due to its cosmetic effect gains more public health importance today. In the scenario of increasing awareness of environmental health hazards, among people, the research into the biology of fluorosis conducted
-
Elevated fluoride levels and periostitis in pediatric hematopoietic stem cell transplant recipients receiving long-term voriconazole
Azole therapy is widely utilized in hematopoietic stem cell transplant (HCT) recipients for the treatment of aspergillus. Complications of voriconazole treatment related to its elevated fluoride content have been described in adults, including reports of symptomatic skeletal fluorosis. We review fluoride levels, clinical, and laboratory data in five pediatric HCT recipients
-
Skeletal fluorosis in relation to drinking water, nutritional status and living habits in rural areas of Maharashtra, India
The present study was carried out during May 2010 to December 2011 in three villages which were randomly selected from Warora tehsil of Chandrapur district which is one of the endemic district of Maharashtra. . . . All the presently available ground water samples were collected and the mean fluoride concentration
-
X-ray changes in the forearm and crus of residents of areas in Jilin Province with varying drinking water fluoride concentrations
GOAL: To understand the characteristics of forearm and crus X-rays of residents from areas with varying concentrations of fluoride in their drinking water, providing evidence for diagnosis of osteofluorosis. METHOD: Using quantificational epidemiological methods, a total of 15 villages from Qianan and Nonan Counties of Jilin Province were selected as the
Related Studies :
-
-
-
Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
-
Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
-
"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
-
Skeletal Changes in Industrial and Endemic Fluorosis
Fluorotic changes in bones and joints were evaluated in 105 aluminum workers and 20 residents of an endemic fluorosis region in India.
-
X-Ray Diagnosis of Skeletal Fluorosis
In 1937, Kaj Roholm published his seminal study Fluorine Intoxication in which he described three phases of bone changes that occur in skeletal fluorosis. (See below). These three phases, which are detectable by x-ray, have been widely used as a diagnostic guide for detecting the disease. They describe an osteosclerotic bone disease that develops first in the axial skeleton (the spine, pelvis, and ribs), and ultimately results in extensive calcification of ligaments and cartilage, as well as bony outgrowths such as osteophytes and exostoses. Subsequent research has found, however, that x-rays provide a very crude measure for diagnosing fluorosis since the disease can cause symptoms and effects (e.g., osteoarthritis) before, and in the absence of, radiologicaly detectable osteosclerosis in the spine.
Related FAN Content :
-