Abstract

Complex studies pertaining to the production of phosphorus-containing mineral products detected no cases of occupational fluorosis among workers. The reasons for fluorosis absence in fluorine-exposed workers were analyzed. The total fluorine load was calculated in workers of the main professions. It was demonstrated that fluorine annual intake of 2-4 g corresponding to the mean-shift concentration of 1-2 mg/m3 (critical levels) required various activities aimed at prevention of occupational fluorosis.

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  • Skeletal fluorosis from eating soil

    A woman with chronic pyelonephritis developed progressive muscular weakness and bone pain. For twenty years she had habitually ingested fluoride-rich soil. Osteosclerosis was found on x-ray examination, and fluorosis was confirmed by bone biopsy. Renal failure augmented skeletal retention of excessive fluoride intake which, in turn, appears to have intensified symptomatic renal

  • [Epidemiology and clinical study of endemic fluorosis in a village that has improved water for 40 years].

    Objective: To investigate the control effect of water improvement for endemic fluorosis over a long period of time, the health status of the residents in the disease area and the restoration to health of endemic fluorosis patients. Methods: It was investigated that the water improvement lasting for 40 years and the rate

  • The effect of fluoride on bone

    Conclusions Although it is well known that the ingestion of high levels of fluoride can give rise to severe lesions in the skeletal tissues, such effects have never been found radiographically in persons using a water supply, containing less than 4 p.p.m fluorlde throughout life. A histological study of thirty ribs taken

  • Reversibility of skeletal fluorosis.

    At two x ray examinations in 1957 and 1967, 17 cases of skeletal fluorosis were identified among long term cryolite workers in Copenhagen. In 1982 four of these patients were alive, eight to 15 years after exposure had ended. Radiographs were obtained, and the urinary fluoride excretion was measured. A

  • Downregulation of miR-4755-5p promotes fluoride-induced osteoblast activation via tageting Cyclin D1.

    Background Endemic fluorosis remains a major public health issue in many countries. Fluoride can cause abnormalities in osteoblast proliferation and activation, leading to skeletal fluorosis. However, its detailed molecular mechanism remains unclear. Based on a previous study, the aim of this study is to explore the role of miRNA in osteoblast

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    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

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