Abstract
Excessive consumption of fluoride through drinking water or other sources lead to skeletal and dental fluorosis. According to the world health organization 23 nations are facing the problem of fluorosis. In the recent past researchers describe the non-skeletal fluorosis where soft tissues and major organs are the victims of fluoride toxicity. Hence in the present study we attempted to investigate the structural changes in various brain areas followed by fluoride exposure and to explore the protective effect of ascorbic acid and Ginkgo biloba against fluoride neurotoxicity. Animals were randomly divided into five groups. Control animals received ordinary water; fluoride animals received fluoride water; all the other animals in the study received gum acacia, ascorbic acid and Ginkgo biloba for first 15 days followed by the fluoride water for 30 days. The present experiment showed fluoride caused neurodegeneration in the form of dark, pyknotic neurons could be apoptosis/ necrosis. However the neurodegeneration is less severe in the ascorbic acid and Ginkgo biloba treated animals. Hence the ascorbic acid and Ginkgo biloba may help as alternate therapeutic strategy to treat fluorosis victims.
Keywords: Fluorosis, Ascorbic acid, Ginkgo biloba, Hippocampus, Amygdala, Motor cortex, Neurotoxicity
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Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain
CONTEXT: Quercetin is a well known aglycone flavonoid that is widely found in different food sources. OBJECTIVE: In this study, the in vivo neuroprotective potential of quercetin against sodium fluoride-induced oxidative stress was evaluated. MATERIALS AND METHODS: Wistar rats were divided into five treatment groups and then subjected to daily
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Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain
Gallic acid is known as a potent antioxidant active compound of the edible and medicinal plant Peltiphyllum peltatum. The main objective of this study was to evaluate the neuroprotective effects of gallic acid against sodium fluoride induced oxidative stress in rat brain. Gallic acid (10 and 20 mg/kg) and vitamin C
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Protective effects of curcumin against fluoride-induced oxidative stress in the rat brain
We examined effects of a plant polyphenolic compound, curcumin, against fluoride-induced oxidative stress in the rat brain. Five experimental groups of male rats (10 animals each) were compared. Animals of these experimental groups were treated with curcumin (10 and 20 mg/kg body mass), vitamin C (10 mg/kg), and sample solvent
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Cytoprotective effects of curcumin on sodium fluoride-induced intoxication in rat erythrocytes
Curcumin is well known for its potent antioxidant activity. The result of numerous studies showed that antioxidants can protect against fluoride-induced toxicity. In the present study, protective effects of curcumin against sodium fluoride-induced toxicity in rat erythrocytes were evaluated. Curcumin (10 and 20 mg/kg) and vitamin C (10 mg/kg) were
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Ameliorative effects of oleanolic acid on fluoride induced metabolic and oxidative dysfunctions in rat brain: experimental and biochemical studies
Beneficial effects of oleanolic acid on fluoride-induced oxidative stress and certain metabolic dysfunctions were studied in four regions of rat brain. Male Wistar rats were treated with sodium fluoride at a dose of 20 mg/kg b.w./day (orally) for 30 days . Results indicate marked reduction in acidic, basic and neutral
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