Abstract
Objective To investigate the mechanism of chronic fluorine poisoning on hippocampus of rats.
Methods The changes of positive nNOS expression in control group given drinking tap water,100 mg/L(low fluorine group),200 mg/L(high fluorine group),were observed by ABC immunohistochemisty.
Results The expression of nNOS in the region of CA1, CA3 and dentate gyrus (DG) in hippocampus of low fluorine group and high fluorine group was significantly reduced, with the increase of fluorine, the expression of nNOS in the region of CA1 was reduced significantly, region CA3 and DG also reduced.
Conclusion Chronic fluorine poisoning can restrain the expression of nNOS in Hippocampus of rats.
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Effect of fluoride on calcium ion concentration and expression of nuclear transcription factor kappa-B p65 in rat hippocampus
The study investigated the neurotoxicity of drinking water fluorosis in rat hippocampus. Just weaning male Sprague-Dawley (SD) rats were given 15, 30, 60 mg/L NaF solution and tap water for 9 months. The calcium ion concentration ([Ca(2+)]) in synaptosomes was measured by double wavelength fluorescence spectrophotometer and the expression level
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Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
Background: Structural brain abnormalities in newborn animals after prolonged exposure to all routinely used general anaesthetics have raised substantial concerns for similar effects occurring in millions of children undergoing surgeries annually. Combining a general anaesthetic with non-injurious sedatives may provide a safer anaesthetic technique. We tested dexmedetomidine as a mitigating
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Detrimental Effects of Sodium Fluoride on the Expression of Insulin Receptor in the Olfactory Bulb and Hippocampus of Male Mice.
Fluoride exposure is associated with lowered cognitive function ability, intelligence quotient, and mental decline, especially in children. The brain insulin receptor (IR) signaling system is related to neuronal plasticity and consequent cognitive ability. In our previous study, NaF exposure decreased IR expressions in olfactory bulb (OB) and hippocampus after Y-maze
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Attenuating effect of Vitamin E on the deficit of learning and memory of rats with chronic fluorosis: the mechanism may involve muscarinic acetylcholine receptors.
The protective role of vitamin E (Vit E) against neurotoxicity induced by fluorosis was investigated by using Sprague-Dawley (SD) rats fed with 50 ppm fluoride in drinking water for 10 months. Spatial learning and memory of rats were measured by the Morris water maze test; the expressions of M1 and
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Protective Effect of Curcumin on Hippocampal and Behavior Changes in Rats Exposed to Fluoride During Pre- and Post-natal Period.
Introduction: Curcumin, a yellow-pigment, found in the popular Indian spice turmeric (Curcuma longa), poses pharmaceutical applications due to its anti-inflammatory, antioxidant, and chemoprotective properties. Excessive fluoride causes fluorosis leading to neurodegeneration and associated behavioral deficits, particularly in children. This study aimed at investigating the neuroprotective ability of curcumin on sodium
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Fluoride Affects Learning & Memory in Animals
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