Abstract

Une enquête épidémiologique sur la fréquence du mongolisme dans quelques Etats du Midwest américain nous a permis de mettre en évidence les faits suivants:

1: un parallélisme entre la fréquence du mongolisme et la teneur en fluor de l’eau de boisson;

2: une rareté relative des caries dentaires chez les mongoliens;

3: une concentration en fluor des dents, relativement plus élevée chez les mongoliens;

4: l’apparition d’une grande fréquence de tumeurs mélaniques chez la Drosophile, sous l’action du fluor, ce qui traduit des modifications du métabolisme du tryptophane, similaires aux déviations métaboliques, génétiquement contrôlées, mises en évidence chez les mongoliens.

• Related Studies :

  • Role des inhibiteurs enzymatiques dans l'etiologie du mongolisme

    1) The low incidence of dental caries observed in mongoloid patients led to an investigation of the role of fluorine in this condition. 2) A statistical study of the geographical distribution of mongolism in Wisconsin, Illinois, Idaho, North and South Dakota (U.S.A.) shows a parallelism between the prevalence of this condition

  • Editorial review: Fluoride and down's syndrome (mongolism)

  • [New researches on mongolism related to the disease producing role of fluorine].

    A new statistical study on the distribution of mongolism in cities in Illinois, United States, from January 1, 1950 to December 31, 1956, permits us to verify an increasing frequency of this affliction associated with the concentration of fluorine in the drinking water. This study follows a preceding inquiry on the

  • Sodium fluoride disrupts DNA methylation of H19 and Peg3 imprinted genes during the early development of mouse embryo

    Sodium fluoride (NaF) is associated with embryonic and fetal development abnormalities, but the mechanism by which this occurs is unclear. DNA methylation, an important epigenetic reprogramming mechanism, is essential for normal embryonic development. Thus, we investigated the effect of NaF on DNA methylation in early mouse embryos, as well as

  • Down syndrome, water fluoridation, and maternal age

    It has been claimed that there is a positive association between the frequency of Down syndrome and the fluoridation of drinking water. It has also been suggested that this association is most pronounced in young women. Recent congenital malformations data obtained from birth certificates from large U.S. cities have been

• Related FAN Content :

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts