Abstract
The prevalence rates of Down’s syndrome at birth were compared for Massachusetts residents ingesting fluoridated and non-fluoridated water. The observations included nearly all children born alive with Down’s syndrome in Massachusetts during the 17-year period 1950-1966. A rate of 1.5 cases per 1000 births was found for fluoride-related births and appropriate comparison groups; the upper bound of a one-sided 95 per cent confidence interval for the ratio of fluoride to non-fluoride rates was 1.2. Thus, the data provide strong evidence that fluoridation does not cause any important elevation in risk for Down’s syndrome, at least not for several years after its introduction.
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Oligophrenie mongolienee et caries dentaires
Une enquête épidémiologique sur la fréquence du mongolisme dans quelques Etats du Midwest américain nous a permis de mettre en évidence les faits suivants: 1: un parallélisme entre la fréquence du mongolisme et la teneur en fluor de l'eau de boisson; 2: une rareté relative des caries dentaires chez les mongoliens; 3: une
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Editorial review: Fluoride and down's syndrome (mongolism)
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[New researches on mongolism related to the disease producing role of fluorine].
A new statistical study on the distribution of mongolism in cities in Illinois, United States, from January 1, 1950 to December 31, 1956, permits us to verify an increasing frequency of this affliction associated with the concentration of fluorine in the drinking water. This study follows a preceding inquiry on the
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Water fluoridation and congenital malformations: no association
Data based on a total number of 1,387,027 births were used to compare the incidence of selected congenital malformations in fluoridated areas and that in areas where the water supply is deficient in fluoride. The incidence of selected congenital malformations in areas with fluoride supplementation of public water supplies was compared
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Fluoride-linked down syndrome births and their estimated occurrence due to water fluoridation
Down syndrome (DS) birth rates (BR) as a function of maternal age exhibit a relatively flat linear regression line for younger mothers and a fairly steep one for older mothers with the second line intersecting the first line a little above maternal age 30. Consequently, overall DS-BR for all maternal
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