Fluoride levels of 600 samples of iliac crest bone in ash weight were correlated with age. They showed a near linearship with age. The yearly rate of accumulation of fluoride in bone was found to be 25.589 ug/g bone ash weight. This accumulation rate could be met by the ingestion of 0.867 mg/day of fluoride. The derivation of this figure is indicated and considered in relation to known ranges of dietary and other levels of fluoride ingestion.
Urinary fluoride patterns among children in Mexico and Canada.
Background: New research suggesting fluoride is a developmental neurotoxicant highlights the importance of characterizing fluoride exposure in children. Fluoride is added to salt in Mexico and to drinking water in Canada to prevent dental caries. We examined the association of childhood urinary fluoride (CUF) with food and water fluoride levels
Fluoride metabolism in man
Fluoride balances were measured in man under strictly controlled dietary conditions before and during the intake of sodium fluoride, and after its discontinuation. Fluoride intake averaged 4.4 mg/day in the control period and 13.8 mg during the addition of an average of 21 mg sodium fluoride/day. The main pathway of
A mathematical model for fluoride uptake by the skeleton
A mathematical model was developed that predicts fluoride accumulation and clearance from the skeleton based upon fluoride bioavailability, bone remodeling rate, and the fluoride binding characteristics of bone. It was assumed that fluoride binds to bone in a nonlinear fashion such that a smaller percentage of fluoride is bound to
Contemporary biological markers of exposure to fluoride.
Contemporary biological markers assess present, or very recent, exposure to fluoride: fluoride concentrations in blood, bone surface, saliva, milk, sweat and urine have been considered. A number of studies relating fluoride concentration in plasma to fluoride dose have been published, but at present there are insufficient data on plasma fluoride
OP V – 2 Prenatal fluoride exposure and neurobehavior among children 1–3 years of age in Mexico
Background/aim Recent studies report an inverse association between fluoride (F) exposure and IQ in children, but few included individual measures of exposure or assessed associations with prenatal exposure using a prospective study design. Methods This study utilised the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort and archived pregnancy samples
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