Abstract
Microscopic examinations were made of 99 bones from 37 persons coming to necropsy who had resided 10 years or more in communities where the drinking water contained 1 to 4 ppm of naturally occurring or artificially added fluoride. Ninety-four bone specimens from 33 controls who had lived in areas where the drinking water contained less than 0.5 ppm fluoride were used for comparison.
In addition to the bone specimens, the lumbar intervertebral body joints of the subjects were examined.
The microscopic examinations showed no significant differences between the fluoride-exposed group and the control group that could be related to fluoride intake. Microscopic changes in the bones and joints incidental to aging and due to non-fluoride-related conditions were observed in both series.
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On mild degrees of fluorosis. 2: An experimental, 2-year-study of rats drinking distilled water containing 0, 1 or 5 ppm F-
24 recently weaned Sprague-Dawley rats were divided equally into 3 groups and given distilled drinking water ad libitum containing 0, 1 or 5 ppm F- (as NaF), respectively. Among the 13 animals that received the fluoridated water and survived the 2-year experimental period, 4 developed macroradiographically demonstrable resorption cavities in
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Chronic fluorosis: the disease and its anaesthetic implications..
Abstract Chronic fluorosis is a widespread disease-related to the ingestion of high levels of fluoride through water and food. Prolonged ingestion of fluoride adversely affects the teeth, bones and other organs and alters their anatomy and physiology. Fluoride excess is a risk factor in cardiovascular disease and other major diseases, including
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Cellular and histochemical characteristics of osteoid formed in experimental fluoride poisoning
The present study on the cellular and histochemical characteristics of osteoid formed in iliac crest bone during fluoride poisoning in rabbits was carried out as there is no information available to date either on its structural or biochemical characteristics. Osteoid formation in bone is prevalent both in fluorosis and in
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Periarticular calcifications containing giant pseudo-crystals of francolite in skeletal fluorosis from 1,1-difluoroethane 'huffing".
Highlights Diagnosing inhalant use disorder can be lifesaving. Chronic inhalation of F--containing vapors can cause skeletal fluorosis (SF). SF can elevate bone density and cause periostitis and ectopic calcification. Francolite is a carbonate-rich fluorapatite. Periarticular calcification in SF can comprise giant pseudo-crystals of francolite. Inhalant use disorder is a psychiatric
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The effect of in vitro fluoride ion treatment on the ultrasonic properties of cortical bone
The mechanical properties of composites are influenced, in part, by the volume fraction, orientation, constituent mechanical properties, and interfacial bonding. Cortical bone tissue represents a short-fibered biological composite where the hydroxyapatite phase is embedded in an organic matrix composed of type I collagen and other noncollagenous proteins. Destructive mechanical testing
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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