Abstract
The aim of this study was to evaluate the effects of fluoride on anxiety and depression in mice. Control and study groups were formed with ten 4-month-old male Swiss mice in each group. For 90 days, mice in the control group were given drinking water containing 0.3 ppm fluoride while the study group was given water with 40 ppm fluoride. Tail suspension was not significantly different between the study and the control groups. In an open field test, however, the number of defecations was higher in the study group, and transitions, rearing, and grooming activities were less frequent. Under these conditions, fluoride appeared to have no antidepressant effect in mice but rather an anxiety stimulating effect.
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Effects of developmental fluoride exposure on rat ultrasonic vocalization, acoustic startle reflex and pre-pulse inhibition
Rats receiving fluoride during the whole pregnancy up to the 9th day of lactation showed, when isolated at 10th day of life, a reduced rate of ultrasonic vocalizations (UV) in male pups (NaF 5.0 mg) and, in 90th days male rats, an increase of the Pre-Pulse Inhibition (PPI) with a reduction of
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Clofibrate, a PPAR-a agonist, abrogates sodium fluoride-induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba-1/anti-calbindin signaling pathways.
Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water, toothpaste, and mouth rinses to prevent tooth decay. Epidemiological findings have demonstrated that exposure to fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, and motor disorders. The neuroprotective
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Fluoride exposure during early adolescence and its association with internalizing symptoms.
Highlights Adolescents with elevated urinary fluoride concentrations exhibit more somatization symptoms. Males may represent an at-risk population for fluoride-related internalizing behaviors. While somatization is typically comorbid with anxiety and depression, fluoride concentrations were not associated with increased depressive or anxiety symptoms. Background Early, chronic, low-level fluoride exposure has been linked to
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[Effects of selenium on the damage of learning-memory ability of mice induced by fluoride].
Sodium fluoride added with or without selenite in deionized water was administered to male mice for 8 weeks. The influences of fluoride on learning-memory behavior were tested on Y-maze, and the ultrastructure of Gray 1 synaptic interface in the CA3 area hippocampus was qualitatively analyzed by electron microscopy and computer
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Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1
Highlights Sodium fluoride (NaF) treatment changed the behaviour of zebrafish. Expression of antioxidant genes was upregulated. Expression of Nrf2 and its related genes were also altered. Results indicated that Nrf2 plays a significant role in NaF induced neurotoxicity. Sodium fluoride (NaF), used as pesticides and for industrial purposes are deposited
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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