Abstract

Endemic fluorosis is a systematic disease. We investigated the serum free fluoride, thyroid hormones and TSH concentrations in 37 cases. Significantly lowered serum T4 and T3 and increased TSH were found in patients. Patients’ serum rT3 concentrations were not significantly different from the controls. Significant negative correlations were found between serum free fluoride concentrations and T3 concentrations or T3/T4 ratios. We proposed that fluoride intoxication might decrease the thyroid function and suggested the method of prevention and treatment of this condition.

• Related Studies :

  • Analysis of the protective effects of y-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.

    CONTEXT: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, y-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. OBJECTIVE: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury

  • [Action of the body fluorine of healthy persons and thyroidopathy patients on the function of hypophyseal-thyroid the system].

    Altogether 123 persons were examined: 47 healthy persons, 43 patients with thyroid hyperfunction and 33 with thyroid hypofunction. It was established that prolonged consumption of drinking water with a raised fluorine content (122 +/- 5 mumol/l with the normal value of 52 +/- 5 mumol/l) by healthy persons caused tension

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    A case-control study was undertaken among the school children aged 8-15 years to know the presence and severity of dental fluorosis, nutrition and kidney status, and thyroid function along with bone metabolic indicators in Doda district situated at high altitude where drinking water was contaminated and heat stress. This study

  • Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India.

    Fluoride (F) is mainly ingested through drinking water and food. In addition to producing dental and skeletal fluorosis, excess fluoride may also affect the functioning of many organs including the thyroid gland. The present study investigated the thyroid function of subjects with dental fluorosis from F-endemic areas of Gaya region,

  • Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride.

    Highlights Sodium fluoride exposure from pregnancy to lactation induces thyroid toxicity. This can affect neurodevelopment and induce behavioural changes. Spirulina platensis role in reversing fluoride-induced toxicity was ascertained. Significant protection was exerted by Spirulina The study investigated the role of Spirulina platensis in reversing sodium fluoride-induced thyroid, neurodevelopment and oxidative alterations

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