Abstract
Endemic fluorosis is a systematic disease. We investigated the serum free fluoride, thyroid hormones and TSH concentrations in 37 cases. Significantly lowered serum T4 and T3 and increased TSH were found in patients. Patients’ serum rT3 concentrations were not significantly different from the controls. Significant negative correlations were found between serum free fluoride concentrations and T3 concentrations or T3/T4 ratios. We proposed that fluoride intoxication might decrease the thyroid function and suggested the method of prevention and treatment of this condition.
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Prevention & control of fluorosis & linked disorders: Developments in the 21st Century - Reaching out to patients in the community & hospital settings for recovery.
The review on fluorosis addresses the genesis of the disease, diagnostic protocols developed, mitigation and recovery through nutritional interventions. It reveals the structural and functional damages caused to skeletal muscle and erythrocytes, leading to clinical manifestations in fluorosis. Hormonal derangements resulting in serious abnormalities in the health of children and
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Effects of chronic fluorosis on thyroxine, triiodothyronine, and protein-bound iodine in cows
This study was conducted to evaluate the effects of chronic fluorosis in cows on their blood serum levels of thyroxine (T4), triiodothyronine (T3), and protein-bound iodine (PBI). Data collected from twenty cows with chronic fluorosis in the Tendurek Mountain region (altitude about 2000 m) in East Anatolia, Turkey, were compared
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Effects of sub-acute fluoride exposure on discrete regions of rat brain associated with thyroid dysfunction: a comparative study
Objectives: In this present in vivo study, it is intended to examine the effects of fluoride on metabolic functions of four discrete regions of rat brain associated with thyroidal insufficiency. Background: Fluoride contamination in drinking water is a major health issue. Adverse health effects of fluoride include dental and muscle fluorosis,
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Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level.
To assess the roles of dietary protein (Pr) and calcium (Ca) level associated with excessive fluoride (F) intake and the impact of dietary Pr, Ca, and F on thyroid function, 144 30-day-old Wistar albino rats were randomly allotted to six groups of 24 (female:male = 1:1). The six groups were
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Fluoride and thyroid function in children in two villages in China
Eighty two children, aged 8 - 13 years old, from Wamiao village (severe endemic fluorosis area), from Xinhuai village (nonendemic fluorosis area) were 88 (as a control group), were recruited in this study. The prevalence of dental fluorosis (DF) were 85.37% (Wamiao) and 6.82% (Xinhuai) in two village’s children respectively;
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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