Abstract
The purpose of this study was to evaluate the relationship between bone mineral loss and urinary fluoride (F) concentration in postmenopausal Japanese women. Lumbar spinal bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) at baseline and 1 year later in 94 premenopausal and 100 postmenopausal women. None of the subjects had any bone-related disorders. There were significant correlations between urinary F concentration and time since menopause (r = 0.397; P < 0.05), and between annual BMD loss and urinary F concentration at baseline (r = -0.492; P < 0.01) in the postmenopausal women. However, there was no significant correlation between urinary F concentration and BMD either at baseline or 1 year later. Urinary F concentration tended to be higher in postmenopausal women with low blood estradiol (E(2)) concentration than in those with normal blood E(2) concentration. Our results suggested that urinary F concentration may be a useful marker to assess bone resorption in postmenopausal women.
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Estimation of the fraction of an ingested dose of fluoride excreted through urine in pre-school children.
Objective: To determine the fraction of an ingested fluoride dose of 1 mg in 50 mL orange juice that is excreted through the urine (FUEF) of children aged 3-5 years. Methods: Eighty-eight controlled determinations involving 24-hour urinary collections from a total of 48 children were carried out
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Urinary fluoride patterns among children in Mexico and Canada.
Background: New research suggesting fluoride is a developmental neurotoxicant highlights the importance of characterizing fluoride exposure in children. Fluoride is added to salt in Mexico and to drinking water in Canada to prevent dental caries. We examined the association of childhood urinary fluoride (CUF) with food and water fluoride levels
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DNA methylation and fluoride exposure in school-age children: Epigenome-wide screening and population-based validation.
Highlights Long-term fluoride exposure affects the genomic DNA methylation pattern in children. The methylation status of NNAT and CALCA are susceptible to long-term F exposure. NNAT gene methylation is negatively correlated with fluoride exposure. CALCA gene methylation and fluoride exposure are positively associated. Excessive fluoride exposure and epigenetic change can
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Longitudinal associations between early-life fluoride exposures and cardiometabolic outcomes in school-aged children.
Highlights • We evaluated longitudinal associations between repeated fluoride measures and cardiometabolic outcomes in children. • Dietary fluoride altered levels of lipids, adipokines, and diabetes-related biomarkers in children during 4–8 years of age. • Dietary fluoride increased zBMI and odds of overweight/obesity status in children at age 8. • Fewer, though
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Fluoride exposure during early adolescence and its association with internalizing symptoms.
Highlights Adolescents with elevated urinary fluoride concentrations exhibit more somatization symptoms. Males may represent an at-risk population for fluoride-related internalizing behaviors. While somatization is typically comorbid with anxiety and depression, fluoride concentrations were not associated with increased depressive or anxiety symptoms. Background Early, chronic, low-level fluoride exposure has been linked to
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Factors which increase the risk for skeletal fluorosis
The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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Kidney Patients Are at Increased Risk of Fluoride Poisoning
It is well established that individuals with kidney disease are susceptible to suffering bone damage and other ill effects from low levels of fluoride exposure. Kidney patients are at elevated risk because when kidneys are damaged they are unable to efficiently excrete fluoride from the body. As a result, kidney patients
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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