Abstract
The purpose was to discover whether fluoride (F) accumulates in the aged human pineal gland. The aims were to determine (a) F-concentrations of the pineal gland (wet), corresponding muscle (wet) and bone (ash); (b) calcium-concentration of the pineal. Pineal, muscle and bone were dissected from 11 aged cadavers and assayed for F using the HMDS-facilitated diffusion, F-ion-specific electrode method. Pineal calcium was determined using atomic absorption spectroscopy. Pineal and muscle contained 297+/-257 and 0.5+/-0.4 mg F/kg wet weight, respectively; bone contained 2,037+/-1,095 mg F/kg ash weight. The pineal contained 16,000+/-11,070 mg Ca/kg wet weight. There was a positive correlation between pineal F and pineal Ca (r = 0.73, p<0.02) but no correlation between pineal F and bone F. By old age, the pineal gland has readily accumulated F and its F/Ca ratio is higher than bone.
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Fluoride exposure and duration and quality of sleep in a Canadian cohort.
Background: Research suggests that fluoride from dietary and environmental sources may concentrate in calcium-containing regions of the body such as the pineal gland. The pineal gland synthesizes melatonin, a hormone that regulates the sleep-wake cycle. We used population-based data from Cycle 3 (2012-2013) of the Canadian Health Measures Survey (CMHS)
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Fluoride in the brain and pineal gland of two duck species, Aythya Fuligula and Melanitta Fusca, wintering in northwestern Poland
Fluoride (F–) deposits formed, e.g., in bones, have hitherto mainly been analyzed in highly mineralized tissues obtained from mammals and only rarely from birds. Under certain conditions, F– may also accumulate significantly in the brain and pineal gland and interfere with the secretion of melatonin by that gland. The mammalian and avian pineal gland is
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The Effect of Fluoride on the Physiology of the Pineal Gland
The purpose was to discover whether fluoride (F) accumulates in the pineal gland and thereby affects pineal physiology during early development. The [F] of 11 aged human pineals and corresponding muscle were determined using the F-electrode following HMDS/acid diffusion. The mean [F] of pineal gland was significantly higher (p <
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Influence of flow rate, pH and plasma fluoride concentrations on fluoride concentration in human parotid saliva
In two separate studies the influence of some physiological factors on salivary fluoride excretion was investigated. In the first study, parotid saliva, at two predetermined flow rates, and capillary blood were sampled after ingestion of 1 mg fluoride. In the second study, parotid saliva was collected at five different flow
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Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India
SUMMARY: Ninety children with dental fluorosis, aged 7–18, living in fluoride endemic, non-iodine deficient areas of the National Capital Territory of Delhi, India, where iodized salt has been promoted for over a decade, were investigated, along with 21 children in two control groups without dental fluorosis living in non- endemic
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Luke (2001): Fluoride Deposition in the Aged Human Pineal Gland
This study has added new knowledge on the fate and distribution of fluoride in the body. It has shown for the first time that fluoride readily accumulates in the human pineal gland although there was considerable inter-individual variation
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Luke (1997): The Effect of Fluoride on the Physiology of the Pineal Gland (Excerpts)
"The results suggest that fluoride is associated with low circulating levels of melatonin and this leads to an accelerated sexual maturation in female gerbils. The results strengthen the hypothesis that the pineal has a role in pubertal development."
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