Abstract
The occupational fluorosis risk factors were estimated in a three- stage study among the workers of aluminum and cryolite plants using dennatoglyphics as a genetic marker. This study helped: 1) to establish the existence of genetic predisposition to fluorosis and develop criteria for estimating it, and 2) to prove that predisposition to fluorosis was associated with the same dermatoglyphic features in the workers of both industrial groups. Multifactorial analysis of the set of 15 genetic and non-genetic factors was performed with the help of pattern recognition methods, and demonstrated reliable (90-100%) discrimination between two groups of workers: those who had developed fluorosis and those who had not. Each of the 15 risk factors under study was examined for the degree and the direction of influence. A PC software program was developed in the course of the study, making possible the estimation of individual predisposition to the disease. The method was used to investigate 397 disease- free workers in the electrolysis shop of an aluminum plant. Predisposition to fluorosis was discovered in 22 of them (5.5%)
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Dementia, aluminum, and fluoride.
Letter to the Editor No abstract available. *See https://doi.org/10.1016/0140-6736(91)92411-T
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Aluminium and fluoride in drinking water in relation to later dementia risk.
Background Environmental risk factors for dementia are poorly understood. Aluminium and fluorine in drinking water have been linked with dementia but uncertainties remain about this relationship. Aims In the largest longitudinal study in this context, we set out to explore the individual effect of aluminium and fluoride in drinking water on dementia risk
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Synergistic oxidative impact of aluminum chloride and sodium fluoride exposure during early stages of brain development in the rat.
Aluminum is widely used in industry and in cooking utensils, especially in countries with low economic and social standards. Fluoride is also used in industry, a major component of toothpaste and is added to the drinking water in many countries to fight teeth decay and cavities. Consequently, the coexistence of
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Comparison of total ionic strength adjustment buffers III and IV in the measurement of fluoride concentration of teas.
BACKGROUND: Tea is the second most consumed drink in the UK and a primary source of hydration; it is an important source of dietary fluoride (F) for consumers and also abundant in aluminium (Al). Varying ranges of F concentrations in teas have been reported worldwide which may be, in part,
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Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats.
Highlight The environmental neurotoxicity of heavy metals and trace elements. The anti-inflammatory/antioxidant properties of berberine against the neurodegenerative disorders. Beberine as multipotent anti-Alzheimer like disorder compound. Heavy metals are reported as neurodegenerative disorders progenitor. They play a role in the precipitation of abnormal ß-amyloid protein and hyper-phosphorylated tau, the main hallmarks
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Factors which increase the risk for skeletal fluorosis
The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,
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Genetic Susceptibility to Fluoride
"The results suggest that genetic factors may contribute to the variation in bone response to fluoride exposure.... The genetic influence on the efficacy and adverse effects has been demonstrated for some medications but has never been demonstrated for bone response to fluoride. The demonstration of such genetic influence on bone
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