Abstract

Objective: To investigate the control effect of water improvement for endemic fluorosis over a long period of time, the health status of the residents in the disease area and the restoration to health of endemic fluorosis patients.

Methods: It was investigated that the water improvement lasting for 40 years and the rate of the dental fluorosis and fluorosis in Erzijing Village of Qian’an County, Jilan Province, where endemic fluorosis seriously prevailed. The rate of dental fluorosis of children aged 8-12 years and adults were examined with Dean’s index. The fluoride content in urine of the children and adults were determined with FSIE methods. A number of the residents took radiography in pelvis, forearm, and shank. The content of calcium (Ca), phosphonium (P), alkaline phosphatase (ALP), urea nitrogen (BUN), and total protein (TP) in serum was determined respectively.

Results: The rate of dental fluorosis was 22.2% and 45.2%, and the fluoride content in urine was 1.51 and 0.89 mg/L respectively in children aged 8-12 years and adults 16 and up. The positive rate of symptoms of fluorosis and of impaired function of bone and joints was 29.3% (57.7% before water improvement) and 14.6% respectively in adults. The skeletal fluorosis was revealed by radiography and the content of serum Ca and TP was lowered in a number of the residents.

Conclusions: It was an effective method by drinking defluoridated water for controlling endemic fluorosis, that is to stop taking in excessive fluoride and to promote excretion of fluoride. Patients with dental fluorosis and skeletal fluorosis are very difficult to thoroughly restore to health even though they have terminated intake of excess fluoride over a long period of time.

• Related Studies :

  • Studies on fluorosis in Mehsana District of North Gujarat.

    A survey was conducted in eighteen fluoride endemic villages in Mehsana District of North Gujarat (India). The individuals afflicted with fluorosis were examined for apparent mottled teeth and skeletal complications. Samples of urine and blood of these individuals along with drinking water were collected and compared with samples obtained from

  • Association of Dietary Calcium Intake with Dental, Skeletal and Non-Skeletal Fluorosis among Women in the Ethiopian Rift Valley.

    Fluorosis is a major public health problem in the Rift Valley of Ethiopia. Low calcium (Ca) intake may worsen fluorosis symptoms. We assessed the occurrence of fluorosis symptoms among women living in high-fluoride (F) communities in South Ethiopia and their associations with dietary Ca intake. Women (n = 270) from

  • Impact of Community Defluoridation on a Village Endemic for Hydric Fluorosis in Rural Karnataka, India.

    Introduction: Excessive intake of fluorides can lead to the development of fluorosis, a serious public health issue in India. The objective of this study was to assess the impact of community defluoridation in preventing fluorosis in Kaiwara village. Methodology: This community interventional trial was conducted in Kaiwara

  • Incidence of fluorosis and urinary fluoride concentration are not always positively correlated with drinking water fluoride level.

    The aim of this study was to assess the effect of fluoride on human health, focusing on the incidence of fluorosis, urinary fluoride concentration and fluoride level in drinking water in three fluoride-affected villages of Birbhum district, West Bengal, India. In one village urinary fluoride concentration was very high along

  • Downregulation of miR-4755-5p promotes fluoride-induced osteoblast activation via tageting Cyclin D1.

    Background Endemic fluorosis remains a major public health issue in many countries. Fluoride can cause abnormalities in osteoblast proliferation and activation, leading to skeletal fluorosis. However, its detailed molecular mechanism remains unclear. Based on a previous study, the aim of this study is to explore the role of miRNA in osteoblast

• Related FAN Content :

  • Skeletal Fluorosis: The Misdiagnosis Problem

    It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

  • "Pre-Skeletal" Fluorosis

    As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.

  • Fluoride & Osteoarthritis

    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

  • Symposium on the non-skeletal phase of chronic fluorosis: The Joints

    Of 300 patients with endemic skeletal fluorosis 187 (110 children and 77 adults) showed evidence of arthritis. The spine, especially its cervical portion, appeared to be mainly involved; elbow, hip and knee joints followed next in order.

  • Similarities between Skeletal Fluorosis and Renal Osteodystrophy

    It is quite possible, and indeed likely, that some kidney patients diagnosed with renal osteodystrophy are either suffering from skeletal fluorosis or their condition is being complicated/exacerbated by fluoride exposure.