Abstract

After the establishment of fluorosis animal model, the gene expression of SNAP-25 was detected in order to provide experimental data for nervous system injury induced by fluoride. The results showed that, compared with the de-ionized water group, SNAP-25 mRNA expression was significantly reduced by fluoride.

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  • [Expression of receptor for advanced glycation endproducts and nuclear factor kB in brain hippocampus of rat with chronic fluorosis].

    Objective  To investigate the expressions of receptor for advanced glycation endproducts (RAGE) and nuclear factor kB (NF-kB) in brain hippocampus of rat with chronic fluorosis, and to reveal the mechanism of brain damage resulted from chronic fluorosis. Methods  Sixty clean grade SD rats were randomly divided to three groups (20 rats

  • Fluoride Alteration of [3H]Glucose Uptake in Wistar Rat Brain and Peripheral Tissues.

    The present study was designed to investigate the role of postnatal fluoride intake on [3H]glucose uptake and transport in rat brain and peripheral tissues. Sodium fluoride (NaF) in a concentration of 10 or 50 ppm was added to the drinking water of adult Wistar rats. The control group received distilled

  • Protective effect of lovastatin on neurotoxicity of excessive fluoride in primary hippocampal neurons

    The  protective  role  of  lovastatin  against  neurotoxicity  induced  by fluorosis was investigated by using primary hippocampal neurons. The cholesterol content,  activity  of  superoxide  dismutase   (SOD),  and  content  of  malondialdehyde (MDA)  were  measured  by  biochemical  assays.  The  cell  viability  was  assessed  by examining  the  rate  of  apoptosis  by  flow   cytometry.  The 

  • Effects of chronic fluorosis on CAMKIIA, C-FOS, BAX, and BCL-2 channel signalling in the hippocampus of rats

    In this study, the neurotoxicity of fluoride (F) in the hippocampus of rats exposed to 15, 30, and 60 mg NaF/L in their drinking water for nine months was investigated. Compared with the control (<0.5 mg F/L), significant increases in the expression of calcium/calmodulin-dependent kinase II alpha (CaMKII?) (F=5.228, p<0.05)

  • Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus

    Highlights Fluoride induced myelin damage in mouse hippocampus. Fluoride shortened the synaptic cleft and thickened the postsynaptic density. Fluoride altered the expressions of CREB, BDNF, and NCAM in hippocampus. To investigate the fluoride-induced neurotoxicity on mice hippocampus, healthy adult mice were exposed to 25, 50, and 100 mg NaF/L for 60 days.

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