Abstract

After the establishment of fluorosis animal model, the gene expression of SNAP-25 was detected in order to provide experimental data for nervous system injury induced by fluoride. The results showed that, compared with the de-ionized water group, SNAP-25 mRNA expression was significantly reduced by fluoride.

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  • Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons.

    The mechanisms underlying the neurotoxicity of endemic fluorosis still remain unknown. To investigate the expression level of neural cell adhesion molecules (NCAM), oxidative stress, and apoptosis induced by fluoride, the primary rat hippocampal neurons were incubated with 20, 40, and 80 mg/l sodium fluoride for 24 h in vitro. The

  • The Effect of Chronic Fluorosis on Calcium Ions and CaMKIIa, and c-fos Expression in the Rat Hippocampus.

    This study investigated neurotoxicity of chronic fluorosis in the rat hippocampus. Newly weaning, male, Sprague-Dawley (SD) rats were administered 15, 30, and 60 mg/L sodium fluoride (NaF) solution (fluorine ion concentration 8.25, 16.50, and 33.00 mg/L, respectively), and tap water, for 18 months. The neurotoxicological mechanism was examined with a focus on intracellular

  • Dose-dependent effects of fluoride on neurochemical milieu in the hippocampus and neocortex of rat brain.

    Effects of fluoride (F) on lipid peroxidation and enzyme activity levels in the hippocampus and neocortex were studied in 6- to 7-week-old female Wistar rats in five groups of six administered intraperitoneal doses of NaF in physiological saline over the range of 0, 1, 5, 10, and 20 mg NaF/kg

  • [Expression of receptor for advanced glycation endproducts and nuclear factor kB in brain hippocampus of rat with chronic fluorosis].

    Objective  To investigate the expressions of receptor for advanced glycation endproducts (RAGE) and nuclear factor kB (NF-kB) in brain hippocampus of rat with chronic fluorosis, and to reveal the mechanism of brain damage resulted from chronic fluorosis. Methods  Sixty clean grade SD rats were randomly divided to three groups (20 rats

  • Effects of perinatal fluoride exposure on the expressions of miR-124 and miR-132 in hippocampus of mouse pups.

    Highlights Maternal fluoride exposure enhanced the expressions of miR-124 and miR-132 in hippocampus of mouse offspring. Fluoride-induced decrease in CREB in mouse hippocampus could result from up-regulation of miR-124. In the feedback loop, fluoride decreased MeCP2 and increased miR-132 in the hippocampus of offspring. To investigate the effects of perinatal fluoride

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