Abstract

Eight 14-week-old male Wistar FL strain rats were administered sodium fluoride in a single intraperitoneal dose (35 mg NaF/kg of bw). After 90 min the rats were fatally anesthetized with ether, and blood samples were taken. Compared to ten control rats, fluoride-treated rats developed hyperglycemia accompanied by a statistically significant increase in the concentration of fluoride, creatinine, and urea and a decrease in the level of protein and calcium in the blood serum. The results indicate disturbances in the filtrating function of kidneys in rats.

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