Abstract
The effect of prolonged administration of NaF on the metabolism of (guinea pig) Purkinje cells in the cerebellar cortex was studied by histochemical methods. Experimentation showed an intensification of the metabolic activity of the mitochondria and probably of the membrane system of the endoplasmic reticulum, activation of the complex of enzymes connected with active transport through membrane structures of cells and the absence of perceptible changes in the process of protein synthesis in experimental animals as compared with controls. The intensified activity of the enymatic complexes is probably connected with the excitation of the neurons provoked by the introduction of a toxic substance.
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Low Prenatal Exposures to Fluoride: Are There Neurotoxic Risks for Children?
As a trace element, fluoride can help ward off dental cavities. Exceptionally high pre- and postnatal exposures, as seen in populations whose drinking water supplies are contaminated by natural fluoride sources, have been implicated in a number of adverse health effects.1,2,3,4 However, less is known about fluoride’s neurotoxic risks at
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Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioural, biochemical, and histopathological alterations in mice
Effect of standardized Bacopa monniera (BM; family: Scrophulariaceae) extract (100 and 300 mg/kg) against sodium fluoride (NaF; 100 and 200 ppm)-induced behavioural, biochemical, and neuropathological alterations in mice was evaluated. Akinesia, rotarod (motor coordination), forced swim test (depression), open field test (anxiety), transfer latency (memory), cholinesterase (ChE), and oxidative stress
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The adverse effect of fluoride on children's intelligence: A systematic review.
The authors conducted a systematic review on published studies to date to investigate the effect of fluoride exposure on children's intelligence quotient (IQ) scores. PSYCHINFO, Web of Science, MEDLINE, SCI, and the China National Knowledge Infrastructure (CNKI) search engines were employed for all documents published up to 2012, in English
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Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health.
In this study, several lines of evidence are provided to show that Na+ , K+ -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and
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Long-term exposure to fluoride as a factor promoting changes in the expression and activity of cyclooxygenases (COX1 and COX2) in various rat brain structures.
Highlights long-term exposure to fluoride during the development leads to the decrease in the expression of COX1 and COX2 in the brain. a statistically significant increase in PGE2 concentration and COX2 immunexpression was observed in hippocampus. exposure to fluoride in the prenatal and neonatal period may result in the development
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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