Abstract

Sixty three patients with endemic fluorosis (36 males/27 females; mean age 33.9+/-8.6years) and 45 age, sex and body mass index (BMI) matched healthy controls (30 males/15 females; mean age 32.7+/-8.8years) were included in this study. Basic echocardiographic measurements, left ventricular diastolic parameters and left ventricular myocardial performance index (MPI) were measured. The left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Doppler. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.9+/-0.1mg/l vs 0.4+/-0.1mg/l respectively; P<0.001). Isovolumic relaxation time (IVRT) and deceleration time (DT) were significantly higher in fluorosis patients than in controls (for IVRT 106.9+/-15.6ms vs 96.7+/-12.2ms; P<0.001 and for DT 211.7+/-30.7ms vs 188.0+/-30.0ms; P<0.001, respectively). MPI was significantly higher in fluorosis patients than in controls (0.62+/-0.15ms vs 0.49+/-0.10ms; P<0.001, respectively). We have shown that chronic fluorosis patients had left ventricular diastolic and global dysfunctions.

• Related Studies :

  • Observations on electrocardiograms in a population living in a region with coal-burning-borne endemic fluorosis after comprehensive controls

    Objective: To observe the electrocardiogram (ECG) changes in the population living in the region with coal-burning-borne endemic fluorosis (EF for short) after comprehensive controls. Methods: People living in a region with coal-burning-borne EF in Bijie City of Guizhou Province were selected and then divided into 4 groups according to the

  • Changes of the heart muscle due to chronic fluorosis. Part 2: Experimental studies on the effects of sodium fluoride upon the heart muscle of rabbits

    In the electrocardiogram of rabbits given sodium fluoride orally, a pattern of myocardial damage was observed, namely depressed ST, inverted T, prolonged QT interval, multifocal ventricular premature contraction, bundle branch block, and pulmonary P. Histologically, regressive degeneration, cellular infiltration, hyperemia, hemorrhages and thickening of vessel wall were noted in the

  • Changes of the heart muscle due to chronic fluorosis. Part 1: Electrocardiogram and cardiac x-rays in inhabitants of a high fluoride zone

    1) The author examined inhabitants of a high fluoride zone (Shionoe village, Kagawa Prefecture, and Odani villAge, Sanyo town, Okayama Prefecture). ln residents of these zones , greater myocardial damage was detected electrocardiographically and dilatation of the cardiac sillouette roentgenograpbically than in n0n-fluoride areas. 2) The myocardial damage appears to

  • Electrocardiographic studies of the inhabitants in high fluoride districts

    1) In the Aso-volcano district, a higher incidence of myocardial damage based on electrocardiographic studies was found in inhabitants of high fluoride communities than in "nonfluoride" villages. 2) In subjects with mottled teeth, greater myocardial damage was encountered electrocardiographically than in persons without mottling in the Asovolcano district. 3) The authors conclude

  • Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children - Original Investigation

    OBJECTIVE: Chronic fluoride poisoning is called fluorosis. The aim of the study was to investigate effects of fluorosis on cardiovascular system in children by measuring QT dispersion (QTd), corrected QT dispersion (QTcd), heart rate variability (HRV) and echocardiography findings. METHODS: Thirty-five children with dental fluorosis and 26 children as control group

• Related FAN Content :

  • Fluoride & Myocardial Damage

    Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha

  • Fluoride & Arteriosclerosis

    Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the

  • Fluoride & Electrocardiogram Abnormalities

    An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems

  • Fluoride & Arterial Calcification

    The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis

  • Fluoride, Blood Pressure and Hypertension

    Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et