Abstract
Sixty three patients with endemic fluorosis (36 males/27 females; mean age 33.9+/-8.6years) and 45 age, sex and body mass index (BMI) matched healthy controls (30 males/15 females; mean age 32.7+/-8.8years) were included in this study. Basic echocardiographic measurements, left ventricular diastolic parameters and left ventricular myocardial performance index (MPI) were measured. The left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Doppler. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.9+/-0.1mg/l vs 0.4+/-0.1mg/l respectively; P<0.001). Isovolumic relaxation time (IVRT) and deceleration time (DT) were significantly higher in fluorosis patients than in controls (for IVRT 106.9+/-15.6ms vs 96.7+/-12.2ms; P<0.001 and for DT 211.7+/-30.7ms vs 188.0+/-30.0ms; P<0.001, respectively). MPI was significantly higher in fluorosis patients than in controls (0.62+/-0.15ms vs 0.49+/-0.10ms; P<0.001, respectively). We have shown that chronic fluorosis patients had left ventricular diastolic and global dysfunctions.
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Clinical and hygienic evaluation of the combined effect of vibration and fluoride in humans
By L. Ya. Tartatovskaya, G.N. Samokhvalova, A.G. Antropov Medical Science Centre of Prophylactics and Protection of the Health Workers in Industrial Enterprises, Ekaterinburg, Russia. The study of the combined action of vibration and intense noise, muscular loads and cooling has made it possible to assess the probability of the development of vibration
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Electrocardiographic evaluation in patients with endemic fluorosis without clinically evident heart disease
Objective: This study was carried out to analyse the electrocardiogram (ECG) in patients with endemic fluorosis. Methods: Fifty six patients with endemic fluorosis and 44 age, sex and body mass index (BMI) matched healthy controls with normal fluoride intake underwent standart 12-lead ECG, urine fluoride level and serum sodium, potassium,
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Analyses of ECGs in 271 cases with dental fluorosis
Our team performed investigations in Yuqing Village and Guanfang Village (1) which were seriously affected by endemic fluorosis, from September to October 1985; those two villages are only 1,500 meters distant from Mangbu District of Zhenxiong County, and the life and production conditions in these two villages are similar to
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Electrocardiogram analysis of patients with skeletal fluorosis
To investigate the degree of myocardial damage resulting from endemic fluorosis, electrocardiograms of 136 skeletal fluorosis patients from an endemic fluorosis area were compared with electrocardiograms of a control group of 40 normal patients from a non-endemic fluorosis area. The results show that fluoride in drinking water consumed over time
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Alterations in electrocardiographic parameters after subacute exposure of fluoride and ameliorative action of aluminium sulphate in goats
Fluorosis or crippling disease is one of the existing environmental challenges for animal and human beings in most parts of the globe. In the present study, sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2,
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Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
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Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
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Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
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Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
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Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
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