Abstract
Fluoride by modifying the activity of mitochondrial enzymes may change their respiration rate. In this study NaF at concentrations 5, 10, and 50 µM had no effect on the State 3 respiration rate of rat cardiac mitochondria with succinate substrate. At a higher concentration of 7.5 mM, a significant (p<0.001) decrease by as much as 120.4 ± 5.7 nmol [O]/min/mg protein occurred in the State 3 respiration rate with succinate. Further increase in NaF concentration (15 and 25 mM) resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner.
Excerpt:
… In summary, NaF at concentrations of 5, 10, and 50 µM had no effect on the State 3 respiration rate of mitochondria oxidizing succinate or pyruvate + malate. However, NaF concentrations of 7.5, 15, and 25 mM resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner. Since topical application of F-containing dental products can lead to accumulation of F in the oral cavity, in some cases at fairly high concentrations (16), such procedures run the risk of possibly inhibiting mitochondrial function in cells of the oral cavity and may even be cardiotoxic as well.
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Stimulation of cAMP accumulation in rat aorta and diaphragm by fluorine containing compounds
Evidence is presented that accumulation of cAMP in isolated rat thoracic aorta and diaphragm is stimulated by several fluorine containing compounds (NaF, Na2PO3F (MFP) and SnF2). Time course experiments with NaF showed that maximal stimulation of cAMP accumulation was observed within 2.5 min. NaF and MFP produced significant increases in
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Chronic fluoride exposure has a role in etiology of coronary artery ectasia: sialic acid/glycosaminoglycan ratio
The sialic acid/glycosaminoglycan ratio was determined in 35 coronary artery ectasia patients and 35 control subjects to determine the possible role of fluoride in the etiology of the disease. The coronary artery ectasia patients and controls were selected from subjects who underwent coronary angiography. The mean serum sialic acid level
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Influence of supplementary vitamins and minerals on lipid peroxidation and redox state in heart, kidney and liver of rats exposed to fluoride.
The effect of fluoride (F) and supplementary vitamins and minerals on lipid peroxidation (LPO) and redox state (RS) in heart , kidney and liver of 40 (4 groups of 10) male Wistar rats were studied. One group of rats was left untreated as control, group 1 was received 5 mg/l
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Aortic calcification in chronic fluoride poisoning: biochemical and electronmicroscopic evidence
Fluoride is known to cause ectopic calcification. The biochemical mechanism(s) involved in the initiation of calcification is not understood and the accompanying ultrastructural changes remain to be elucidated. Therefore, certain relevant parameters have been investigated in the aorta of rabbits administered fluoride, 10 mg NaF/kg body wt, every 24 hr
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Changes of certain oxidative, anti-oxidative and vascular function indexes of New Zealand rabbit exposed by high-fluoride.
OBJECTIVE: To observe certain changes of oxidation, anti-oxidation and vascular function indexes of Application of New Zealand rabbit exposed by high-fluoride. METHODS: 20 male New Zealand rabbits were randomly divided into control group, drunk deionized water and feed basic diet. High-fat group, drunk deionized water and feed basic diet plus 0.5%
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