Abstract

Fluoride by modifying the activity of mitochondrial enzymes may change their respiration rate. In this study NaF at concentrations 5, 10, and 50 µM had no effect on the State 3 respiration rate of rat cardiac mitochondria with succinate substrate. At a higher concentration of 7.5 mM, a significant (p<0.001) decrease by as much as 120.4 ± 5.7 nmol [O]/min/mg protein occurred in the State 3 respiration rate with succinate. Further increase in NaF concentration (15 and 25 mM) resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner.

Excerpt:

… In summary, NaF at concentrations of 5, 10, and 50 µM had no effect on the State 3 respiration rate of mitochondria oxidizing succinate or pyruvate + malate. However, NaF concentrations of 7.5, 15, and 25 mM resulted in a reproducible decrease in the oxidation rate of the succinate in dose-dependent manner. Since topical application of F-containing dental products can lead to accumulation of F in the oral cavity, in some cases at fairly high concentrations (16), such procedures run the risk of possibly inhibiting mitochondrial function in cells of the oral cavity and may even be cardiotoxic as well.

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