Abstract
The effect of fluoride (F) and supplementary vitamins and minerals on lipid peroxidation (LPO) and redox state (RS) in heart , kidney and liver of 40 (4 groups of 10) male Wistar rats were studied. One group of rats was left untreated as control, group 1 was received 5 mg/l NaF in their drinking water, group 2 was received 5 mg/l NaF in their drinking water plus vitamins (A, C, and D) in their diet, and group 3 was received 5 mg/l NaF in their drinking water plus vitamins (A, C, and D) and minerals (Mg-, Mn-, Zn-sulfate, and Na-citrate) in their diet. In comparison with the group 2, 3 and controls, elevated malondialdehyde (MDA) content in the group 1 indicated an increase in LPO product. In addition, unsteady ratios of oxidized to reduced nicotinamide adenine dinucleotide (NAD+/NADH) reflected significant alterations in the RS status. These results demonstrate that the combination of vitamins and minerals supplementation proved to restore MDA content and establish steady RS status that has not been previously reported.
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Fluoride-induced neuronal oxidative stress amelioration by antioxidants in developing rats
Premated 3-month-old albino rats received 200-ppm fluoride ion (F) in their drinking water; the pups born to them were separately administered, in groups of six, daily doses of clinoptilolite, zinc, selenium, vitamin C, vitamin D, and propolis. On post-partum day 45, the pups were sacrificed, brain regions separated, and oxidative
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Fetotoxicity of fluoride in rats and the protective action of some antioxidants
The aim of this study was to assess the efficacy of antioxidants to prevent or alleviate fluoride (F) toxicity in pregnant female Wistar rats and their fetuses. Groups of pregnant rats (10 in each group) were treated by oral intubation with F (40 mg F – /kg bw/day from NaF),
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Amelioration of fluoride toxicity by vitamins and calcium on reproductive organs of female rat
Normal female rats of Wistar strain (Rattus norvegicus) weighing between 150–200 g were treated with fluoride (Fl) contaminated drinking water (FW, 5.8 ppm), vitamin C (6 mg) and vitamin C (6 mg) + D (6 mg once a week) + calcium (6 mg) for 30 days. Fl water treatment to
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Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats.
Fluoride (F-) is becoming an ineluctable environmental pollutant causing deleterious effects in humans. In the present study, we examined whether tamarind seed coat extract (TSCE) is beneficial against the F--induced systemic toxicity and hematological changes. Wistar rats were randomly grouped as follows: group I served as control; group II intoxicated
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The effect of high fluoride intake on tissue trace elements and histology of testicular tubules in the rat
1. Male Wistar rats were exposed to fluoride (F) at concentrations of 100- and 200 ppm in their drinking water for 6- and 16 weeks. 2. The high F intake caused several-fold increase in the F concentrations in the testes and bone as compared with control rats, both after the
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Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
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Fluoride & Arteriosclerosis
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoride Exposure Increases Metabolic Requirement for Magnesium
Fluoride's toxicity is significantly enhanced in the presence of nutritional deficiencies. Similarly, fluoride exposure increases the body's requirement for certain nutrients. An individual with a high intake of fluoride, for example, will need a proportional increase in calcium to avoid the mineralization defects (e.g., osteomalacia) that fluoride causes to bone
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