Abstract

Physiologic and hygienic aspects of the absorption of inorganic fluorides are reviewed. Three basic shortcomings in fluoride research are noted: its intake into the system, assimilation, and excretion are subject to great variation between persons; in contrast to extensive biochemical advances in fluoride research, relatively little clinical data is available on how fluoride affects the human organism; and although it is one of the most reactive of all elements, it has been studied in teeth and bone, but not in other organs and tissues. Inconsistencies in data on metabolism can be attributed to wide variation in concentrations ingested with food or inhaled in air, and to individual differences in absorption and excretion. Although several authors report that in endemic areas fluorosis is not uncommon among the inhabitants, clinical details on fluorosis from drinking water as well as from industrial hazards are rare. Data concerning fluoride storage in soft tissues (including liver, kidney, brain, lung, spleen, thyroid, stomach, pancreas, muscle, skin, bladder, heart, aorta, prostate, adrenal, gall bladder, and bone marrow) are reviewed.

• Related Studies :

  • Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.

    Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary

  • Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis

    1. Stomach, duodenum, small intestine, kidney, liver, spleen, skin, heart, aorta, lungs, brain, pancreas, adrenals, thyroid and parathyroid of rats and monkeys suffering from chronic fluorosis have been histologically examined. 2. Fluorine has not been found to have any effect on the heart muscle, aorta, skin and parathyroids, whereas it has

  • A fatality due to ingestion of hydrofluoric acid.

    We report a fatal case of hydrofluoric acid (HF) ingestion with suicidal intent. Quantitation using an ion-selective electrode for fluoride in fresh bile, gastric contents, kidney, liver, skeletal muscle, urine, and vitreous humor yielded 6.5, 39.0, 10.0, 6.0, 4.5, 5.0, and 4.5 ppm, respectively. In addition to the unfixed specimens,

  • Studies on the DNA and RNA contents of heart, liver and kidney of rats with chronic fluorosis

    17 rats with chronic fluorosis induced by prolonged drinking of water containing 50 ppm fluorine and 17 rats drinking low-fluorine water served as control were used to study the DNA and RNA contents of heart, liver and kidney. The findings suggest that excessive accumulation of fluorine can suppress the synthesis

  • The clinical features of 160 cases of acute sodium silicon fluoride poisoning.

    160 cases of acute sodium silicon fluoride poisoning due to accidental intake are reported in this paper. Owing to the great amount of the chemical taken, the onset was abrupt and the digestive symptoms were prominent and severe. Twelve cases had acute gastritis or acute ulceration as shown by gastroscopy.

• Related FAN Content :

  • Fluoride & Arteriosclerosis

    Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the

  • Fluorine in the Aetiology of Endemic Goitre

    The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.

  • Fluoride's Impact on Thyroid Hormones

    Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as

  • NRC (2006): Fluoride's Impact on the Thyroid Gland

    Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.

  • Fluoride Exposure Aggravates the Impact of Iodine Deficiency

    A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and